221290-72-8

Upstream product

• 221290-59-1 (E)-4-[(1R,5R,6R)-6-dimethoxymethyl-5-isopropyl-2-methyl-cyclohex-2-enyl]-2-methyl-but-2-en-1-ol 
• 221290-54-6 (4R,5R)-4-dimethoxymethyl-5-isopropyl-2-methyl-cyclohex-2-enone 
• 221290-57-9 [(1R,5R,6R)-6-dimethoxymethyl-5-isopropyl-2-methyl-cyclohex-2-enyl]-acetaldehyde 
• 221290-71-7 acetic acid (1S,4R,5R)-4-dimethoxymethyl-5-isopropyl-2-methylcyclohex-2-enyl ester 
• 380414-42-6 2-((1R,5R,6R)-6-Dimethoxymethyl-5-isopropyl-2-methyl-cyclohex-2-enyl)-ethanol 
• 221290-56-8 [(1R,5R,6R)-6-dimethoxymethyl-5-isopropyl-2-methyl-cyclohex-2-enyl]-acetic acid 
• 33375-08-5 (R)-5-isopropyl-2-methylcyclohex-2-enone 
• 291520-38-2 (4R,5R)-5-Dimethoxymethyl-4-isopropyl-1-methyl-6-methylene-cyclohexene 
• 291520-37-1 1-methyl-(4S)-isopropyl-(5R)-dimethyl acetal-1-cyclohexen-6-one 
• 2244-16-8 (S)-p-mentha-6,8-dien-2-one 
• 380414-34-6 (E)-4-[(1R,5R,6R)-6-dimethoxymethyl-5-isopropyl-2-methyl-cyclohex-2-enyl]-2-methyl-but-2-enoic acid 

Downstream Products

• 380414-35-7 (2S,3R)-3-[(1R,5R,6R)-6-dimethoxymethyl-5-isopropyl-2-methyl-cyclohex-2-enylmethyl]-2-methyl-oxirane-2-carbaldehyde 
• 221290-75-1 (Z)-{(5S)-5-[(1R)-2-((1R,5R,6R)-6-dimethoxymethyl-5-isopropyl-2-methyl-cyclohex-2-enyl)-1-hydroxyethyl]-5-methyl-5H-furan-2-ylidene}-acetic acid ethyl ester 

Relevant academic research and scientific papers

Synthetic studies on the sarcodictyins: Synthesis of fully functionalized cyclization precursors

A strategy featuring a key retrosynthetic disconnection at the C2-C3 position was applied to the total synthesis of the common diterpenoid tricyclic skeleton of sarcodictyins and eleutherobin. Fully functionalized cyclization precursors were accessed via a brief and convergent route, making use of unprecedented synthetic transformations.

Studies on the stereoselective synthesis of the marine antitumor agent eleutherobin

(+)-Carvone has been converted into the sulfone 14 which comprises the left-hand side of the cytotoxic sesquiterpene, eleutherobin 1. Julia coupling of 14 to the aldehyde 21, followed by oxidation, dissolving metal reduction and stereoselective reduction

Synthetic studies on sarcodictyins and eleutherobin: Synthesis of fully functionalized cyclization precursors

Unprecedented synthetic transformations were demonstrated during the preparation of fully functionalized cyclization precursors of type 2, in a synthetic approach to sarcodictyin A and B (1a,b) and eleutherobin (1c).