221300-34-1

Basic information

• Product Name: 1H-Pyrazole-3-carboxylicacid,4-fluoro-,ethylester(9CI)
• Synonyms: 1H-Pyrazole-3-carboxylicacid,4-fluoro-,ethylester(9CI);ethyl 4-fluoro-1H-pyrazole-3-carboxylate
• CAS NO: 221300-34-1
• Molecular Formula: C₆H₇FN₂O₂
• Molecular Weight: 158.13
• Product Categories: GLYCINESCAFFOLD;HALIDE;CARBOXYLICESTER
• Mol File: 221300-34-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Pyrazole-3-carboxylicacid,4-fluoro-,ethylester(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-3-carboxylicacid,4-fluoro-,ethylester(9CI)(221300-34-1)
• EPA Substance Registry System: 1H-Pyrazole-3-carboxylicacid,4-fluoro-,ethylester(9CI)(221300-34-1)

Safety Data

• Hazardous Substances Data: 221300-34-1(Hazardous Substances Data)

Usage

Structure

1H-Pyrazole-3-carboxylic acid derivative with a fluorine substituent at the 4-position and an ethyl ester group

Type

Organic compound

Use

Intermediate in the synthesis of pharmaceuticals and agrochemicals

Potential applications

Development of new drugs and crop protection products

Fields of interest

Medicinal chemistry, pharmaceuticals, and agriculture

Upstream product

• 5932-27-4 ethyl 1H-pyrazole-3-carboxylate 
• 623-47-2 propynoic acid ethyl ester 

Downstream Products

• 881668-91-3 4-fluoropyrazole-3-carboxylic acid 
• 1621-91-6 1H-pyrazole-3-carboxylic acid 

Relevant articles and documents

The synthesis and antiviral activity of 4-fluoro-1-β-D-ribofuranosyl- 1h-pyrazole-3-carboxamide

A novel fluoropyrazole ribonucleoside has been shown to have significant antiinfluenza activity in vitro. The compound is compared and contrasted with the structurally-related compound ribavirin in attempts to identify factors having significant bearing on the mode of action of both compounds.

3-Substituted pyrazoles and 4-substituted triazoles as inhibitors of human 15-lipoxygenase-1

Investigation of 1N-substituted pyrazole-3-carboxanilides as 15-lipoxygenase-1 (15-LOX-1) inhibitors demonstrated that the 1N-substituent was not essential for activity or selectivity. Additional halogen substituents on the pyrazole ring, however, increased activity. Further development led to triazole-4-carboxanilides and 2-(3-pyrazolyl) benzoxazoles, which are potent and selective 15-LOX-1 inhibitors.

PYRAZOLES USEFUL IN THE TREATMENT OF INFLAMMATION

There is provided compounds of formula (I), wherein R1, R2, X1, X2 and n have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a lipoxygenase (e.g. 15-lipoxygenase) is desired and/or required, and particularly in the treatment of inflammation.

PYRAZOLE COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATION

There is provided compounds of formula (I), wherein R1, R2, Ra and Rb have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a lipoxygenase (e.g. 15-lipoxygenase) is desired and/or required, and particularly in the treatment of inflammation.