221322-07-2 Usage
General Description
2-(2,2-dimethyl-propionyloxymethyl)-thiazole-4-carboxylic acid is a chemical compound with a molecular formula C12H17NO4S. It is a derivative of thiazole-4-carboxylic acid and is synthesized by introducing a 2,2-dimethyl-propionyloxymethyl group onto the thiazole ring. 2-(2,2-DIMETHYL-PROPIONYLOXYMETHYL)-THIAZOLE-4-CARBOXYLIC ACID has potential pharmaceutical applications, particularly as an antibacterial or antifungal agent, due to its thiazole ring structure which is known for its antimicrobial properties. Additionally, the 2,2-dimethyl group contributes to the compound's stability and lipophilicity, making it a promising candidate for drug development. Further research and testing are needed to fully determine the potential uses and benefits of 2-(2,2-dimethyl-propionyloxymethyl)-thiazole-4-carboxylic acid.
Check Digit Verification of cas no
The CAS Registry Mumber 221322-07-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,1,3,2 and 2 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 221322-07:
(8*2)+(7*2)+(6*1)+(5*3)+(4*2)+(3*2)+(2*0)+(1*7)=72
72 % 10 = 2
So 221322-07-2 is a valid CAS Registry Number.
InChI:InChI=1/C10H13NO4S/c1-10(2,3)9(14)15-4-7-11-6(5-16-7)8(12)13/h5H,4H2,1-3H3,(H,12,13)
221322-07-2Relevant articles and documents
Heterocyclic replacement of the central phenyl core of diamine-based histamine H3 receptor antagonists
Swanson, Devin M.,Shah, Chandra R.,Lord, Brian,Morton, Kirsten,Dvorak, Lisa K.,Mazur, Curt,Apodaca, Richard,Xiao, Wei,Boggs, Jamin D.,Feinstein, Mark,Wilson, Sandy J.,Barbier, Ann J.,Bonaventure, Pascal,Lovenberg, Timothy W.,Carruthers, Nicholas I.
, p. 4413 - 4425 (2009)
A series of small molecules consisting of a heterocyclic core flanked by two basic functionalities were synthesized and screened for in vitro affinity at the human histamine H3 receptor (hH3R). Nine of the twenty-eight compounds tested were found to possess a hH3R Ki of less than 5 nM and consisted of a diverse range of central hetero-aromatic linkers (pyridine, pyrazine, oxazole, isoxazole, thiazole, furan, thiophene, and pyrrole). One member of this series, (4-isopropyl-piperazin-1-yl)-(6-piperidin-1-ylmethyl-pyridin-3-yl)-methanone (37), was found to be a high affinity, selective antagonist that crosses the blood-brain barrier and occupies H3 receptors after oral administration in the rat.
N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists
-
, (2008/06/13)
Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are effective as NMDA NR2B antagonists useful for relieving pain.
