221345-18-2Relevant academic research and scientific papers
Palladium-mediated regiodivergent kinetic resolution
Cook, Gregory R.,Sankaranarayanan
, p. 3531 - 3533 (2001)
(metrix presented) racemic substrate optically active regioisomers of opposite configuration The allylic substitution of racemic 5-vinyloxazolidinones with phthalimide and a chiral palladium catalyst afforded optically enriched regioisomeric products. Optimal divergence was found by employing chiral DIOP ligands in toluene. These results demonstrate the influence of chiral ligand/chiral substrate matching on the regioselectivity in a novel resolution strategy.
Hydrogen bond directed highly regioselective palladium-catalyzed allylic substitution
Cook, Gregory R.,Yu, Hui,Sankaranarayanan,Shanker, P. Sathya
, p. 5115 - 5120 (2003)
The palladium-catalyzed allylic substitution of 5-vinyloxazolidinones and derivatives was investigated. Unusual and high regioselectivity for the branched product was observed. The regioselectivity was influenced by the type of substrate, the solvents, an
