221349-87-7Relevant academic research and scientific papers
Bicyclic pyridones as potent, efficacious and orally bioavailable thrombin inhibitors
Coburn, Craig A.,Rush, Diane M.,Williams, Peter D.,Homnick, Carl,Lyle, Elizabeth A.,Lewis, S. Dale,Lucas Jr., Bobby J.,Di Muzio-Mower, Jillian M.,Juliano, Marylou,Krueger, Julie A.,Vastag, Kari,Chen, I-Wu,Vacca, Joseph P.
, p. 1069 - 1072 (2007/10/03)
A new class of conformationally constrained thrombin inhibitors is described. These compounds contain a unique bicyclic pyridone scaffold which serves as a P3P2 dipeptide surrogate. The synthesis and antithrombotic activity of these inhibitors is reported. (C) 2000 Elsevier Science Ltd. All rights reserved.
