221373-13-3

Upstream product

• 132375-32-7 2,2-Dimethyl-propionic acid (3R,6R)-5,5-bis-ethylsulfanyl-6-formyl-tetrahydro-pyran-3-yl ester 
• 221373-06-4 2,2-Dimethyl-propionic acid (3R,6R)-6-(tert-butyl-diphenyl-silanyloxymethyl)-5,5-bis-ethylsulfanyl-tetrahydro-pyran-3-yl ester 
• 221373-05-3 (3R,6R)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-5,5-bis-ethylsulfanyl-tetrahydro-pyran-3-ol 
• 221373-04-2 (2R,5R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-5-hydroxy-dihydro-pyran-3-one 
• 221373-01-9 (1S,4R,5R,6R)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-3,7-dioxa-bicyclo[4.1.0]heptan-5-ol 
• 221373-02-0 (1S,4R,6S)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-3,7-dioxa-bicyclo[4.1.0]heptan-5-one 
• 221372-98-1 2-(tert-butyl-diphenyl-silanyloxymethyl)-3,6-dihydro-2H-pyran-3-ol 
• 132375-42-9 2,2-Dimethyl-propionic acid (3R,6R)-5,5-bis-ethylsulfanyl-6-hydroxymethyl-tetrahydro-pyran-3-yl ester 
• 3282-30-2 pivaloyl chloride 
• 125901-90-8 (2R,3S)-2-(hydroxymethyl)-3,6-dihydro-2H-pyran-3-ol 

Downstream Products

• 221373-17-7 2,2-Dimethyl-propionic acid (3R,6R)-5,5-bis-ethylsulfanyl-6-[(Z)-3-((2R,4S,5R)-5-hydroxy-2-phenyl-[1,3]dioxan-4-yl)-propenyl]-tetrahydro-pyran-3-yl ester 

Relevant academic research and scientific papers

Total synthesis of brevetoxin A: Part 1: First generation strategy and construction of BCD ring system

Discussed herein is our first generation strategy for the total synthesis of brevetoxin A. This approach relies upon dissection of the molecule at the nine-membered ring site (ring E). A Wittig coupling of requisite polycyclic fragments 3 and 4 followed b