221379-75-5

Upstream product

• 22900-10-3 2-deoxy-D-ribose 
• 193970-36-4 (6Z,9Z)-(2R,4aR,11aS)-2-Phenyl-6-vinyl-4a,8,11,11a-tetrahydro-4H-1,3,5-trioxa-benzocyclononene 
• 250226-93-8 (E)-4-((2R,4S,5R)-5-Hydroxy-2-phenyl-[1,3]dioxan-4-yl)-but-2-enoic acid methyl ester 
• 213815-23-7 (E)-4-[(2R,4S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-[1,3]dioxan-4-yl]-but-2-enoic acid methyl ester 
• 193970-34-2 Phosphoric acid diphenyl ester (6E,9Z)-(2R,4aR,11aS)-2-phenyl-4a,8,11,11a-tetrahydro-4H-1,3,5-trioxa-benzocyclononen-6-yl ester 
• 193970-32-0 (Z)-(2R,4aR,11aS)-2-Phenyl-4,4a,7,8,11,11a-hexahydro-1,3,5-trioxa-benzocyclononen-6-one 
• 193970-24-0 (2R,4S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-4-[(Z)-6-(tert-butyl-dimethyl-silanyloxy)-hex-2-enyl]-2-phenyl-[1,3]dioxane 
• 193970-37-5 (Z)-(3R,4aS,13aR)-3-Phenyl-4a,5,8,8a,11,13a-hexahydro-1H-2,4,9,10,13-pentaoxa-dibenzo[a,d]cyclononene 
• 193970-30-8 (Z)-6-((2R,4S,5R)-5-Hydroxy-2-phenyl-[1,3]dioxan-4-yl)-hex-4-enoic acid 
• 193970-28-4 (Z)-6-((2R,4S,5R)-5-Hydroxy-2-phenyl-[1,3]dioxan-4-yl)-hex-4-enal 
• 193970-26-2 (2R,4S,5R)-4-((Z)-6-Hydroxy-hex-2-enyl)-2-phenyl-[1,3]dioxan-5-ol 
• 193970-21-7 [(2R,4S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-[1,3]dioxan-4-yl]-acetaldehyde 
• 78606-78-7 methyl (E,5S,6R)-5,6,7-trihydroxyhept-2-enoate 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 221379-86-8 (Z)-(1S,3R,6R,8S,13R)-15,15-Dimethyl-6-phenyl-2,5,7,14,16-pentaoxa-tricyclo[11.5.0.0^3,8]octadec-10-ene 
• 193970-47-7 (Z)-(2R,4aR,6S,7R,11aS)-6-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-phenyl-4a,6,7,8,11,11a-hexahydro-4H-1,3,5-trioxa-benzocyclononen-7-ol 
• 221379-77-7 2,2-Dimethyl-propionic acid (Z)-(2R,4aR,6S,7R,11aS)-6-(2-iodo-ethyl)-2-phenyl-4a,6,7,8,11,11a-hexahydro-4H-1,3,5-trioxa-benzocyclononen-7-yl ester 
• 193970-51-3 2,2-Dimethyl-propionic acid (Z)-(2R,4aR,6S,7R,11aS)-6-(2-hydroxy-ethyl)-2-phenyl-4a,6,7,8,11,11a-hexahydro-4H-1,3,5-trioxa-benzocyclononen-7-yl ester 
• 221379-76-6 2,2-Dimethyl-propionic acid (Z)-(2R,4aR,6S,7R,11aS)-6-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2-phenyl-4a,6,7,8,11,11a-hexahydro-4H-1,3,5-trioxa-benzocyclononen-7-yl ester 
• 221379-83-5 (Z)-(2R,4aR,6S,7R,11aS)-6-[(Z)-3-((4aS,6R,10aR)-7,7-Bis-ethylsulfanyl-octahydro-1,5-dioxa-benzocycloocten-6-yl)-allyl]-2-phenyl-4a,6,7,8,11,11a-hexahydro-4H-1,3,5-trioxa-benzocyclononen-7-ol 
• 221379-82-4 2,2-Dimethyl-propionic acid (Z)-(2R,4aR,6S,7R,11aS)-6-[(Z)-3-((4aS,6R,10aR)-7,7-bis-ethylsulfanyl-octahydro-1,5-dioxa-benzocycloocten-6-yl)-allyl]-2-phenyl-4a,6,7,8,11,11a-hexahydro-4H-1,3,5-trioxa-benzocyclononen-7-yl ester 
• 221379-85-7 (Z)-(2R,4aR,6S,7R,11aS)-6-(2-Hydroxy-ethyl)-2-phenyl-4a,6,7,8,11,11a-hexahydro-4H-1,3,5-trioxa-benzocyclononen-7-ol 
• 193970-43-3 (Z)-(2R,4aR,11aS)-6-[2-(tert-Butyl-dimethyl-silanyloxy)-eth-(E)-ylidene]-2-phenyl-4a,8,11,11a-tetrahydro-4H-1,3,5-trioxa-benzocyclononen-7-one 

Relevant academic research and scientific papers

Total synthesis of brevetoxin A: Part 2: Second generation strategy and construction of EFGH model system

Our second generation strategy for the total synthesis of brevetoxin A involved dissection of the molecule at the ring F oxocene. Synthetically, the F ring formation was expected to occur through Wittig coupling of requisite polycyclic fragments 2 and 3,