221387-06-0Relevant academic research and scientific papers
C3-thia and C3-carba isosteres of a carbocyclic influenza neuraminidase inhibitor, (3R,4R,5S).4-acetamido-5-amino-3-propoxy-1-cyclohexene-1-carboxylic acid
Lew, Willard,Williams, Matthew A.,Mendel, Dirk B.,Escarpe, Paul A.,Kim, Choung U.
, p. 1843 - 1846 (1997)
The importance of the oxygen atom in the C3 ether side chain of a carbocyclic influenza neuraminidase inhibitor 3 was investigated by replacement of the C3 ether oxygen atom of 3 with either a sulfur atom (compound 4) or a carbon atom (compound 5). The regio- and stereospecific syntheses of both isoteres are described starting from (-)-quinic acid.
