Bioorganic and Medicinal Chemistry Letters p. 1843 - 1846 (1997)
Update date:2022-08-05
Topics:
Lew, Willard
Williams, Matthew A.
Mendel, Dirk B.
Escarpe, Paul A.
Kim, Choung U.
The importance of the oxygen atom in the C3 ether side chain of a carbocyclic influenza neuraminidase inhibitor 3 was investigated by replacement of the C3 ether oxygen atom of 3 with either a sulfur atom (compound 4) or a carbon atom (compound 5). The regio- and stereospecific syntheses of both isoteres are described starting from (-)-quinic acid.
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