95674-54-7Relevant academic research and scientific papers
The synthesis and biological activity of a series of 2,4- diaminopyrido[2,3-d]pyrimidine based antifolates as antineoplastic and antiarthritic agents
Gossett, Lynn S.,Habeck, Lillian L.,Shackelford, Katherine A.,Mendelsohn, Laurane G.,Gates, Susan B.,Worzalla, John F.,Self, Tracy D.,Theobald, Karla S.,Andis, Sherri L.,Schultz, Richard M.,Chuan, Shih
, p. 75 - 78 (2007/10/03)
A new series of 2,4-diaminopyrido[2,3-d]pyrimidine based antifolates 1- 3 were synthesized through an efficient conversion of 2-pivaloyl-4-oxo-6- ethynylpyrido[2,3-d]pyrimidine 5 to the corresponding 4-amino analog 7 via the activated 1,2,4-triazole inter
Synthesis of the Antileucemic Agents 5,10-Dideazaaminopterin and 5,10-Dideaza-5,6,7,8-tetrahydroaminopterin
Taylor, Edward C.,Harrington, Peter J.,Fletcher, Stephen R.,Beardsley, G. Peter,Moran, Richard, G.
, p. 914 - 921 (2007/10/02)
Total syntheses from pyridine precursors of 5,10-dideazaaminopterin (1) and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin (2) are described.These compounds exhibit significant in vivo activity against L1210 leukemia that comparable to that observed with meth
Derivatives of 11-(1-Piperazinyl)-5H-pyrrolobenzodiazepine as Central Nervous System Agents
Wright, William B.,Greenblatt, Eugene N.,Day, Ivana P.,Quinones, Nicanor Q.,Hardy, Robert A.
, p. 462 - 465 (2007/10/02)
Four 11-(1-piperazinyl)5H-pyrrolobenzodiazepines were prepared and evaluated as central nervous system agents.All were active psychotropic agents as determined by animal screening tests.The most interesting compound, 11-(1-piperazinyl)-5H-pyrrolobenzodiazepine, showed dual activity as an antidepressant against tetrabenazine depression and as a neuroleptic as measured by protection vs. amphetamine lethality in grouped mice.
