221525-91-3

Upstream product

• 221525-65-1 (2S,3S)-2-((S)-5-Benzyloxycarbonylamino-1-methoxycarbonyl-pentylcarbamoyl)-3-phenyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 221525-69-5 (S)-6-Benzyloxycarbonylamino-2-[((2S,3S)-3-phenyl-pyrrolidine-2-carbonyl)-amino]-hexanoic acid methyl ester 
• 462124-94-3 (2S,3S)-1-(tert-butoxycarbonyl)-3-phenylpyrrolidine-2-carboxylic acid 
• 479630-66-5 methyl 2-((trifluoromethylsulfonyl)oxy)-3-phenylpropanoate 
• 147291-66-5 3-tert-butoxycarbonylaminomethylaniline 
• 118758-49-9 (2S,3S)-3-phenyl-pyrrolidine-2-carboxylic acid 
• 24498-31-5 (S)-methyl 2-amino-6-(benzyloxycarbonylamino)hexanoate 
• 221525-83-3 (S)-6-Benzyloxycarbonylamino-2-[((2S,3S)-1-{(S)-2-[3-(tert-butoxycarbonylamino-methyl)-phenylamino]-3-phenyl-propionyl}-3-phenyl-pyrrolidine-2-carbonyl)-amino]-hexanoic acid methyl ester 

Downstream Products

• 221526-03-0 [4-((3S,8S,9S,12S)-3-Benzyl-4,10,13-trioxo-8-phenyl-2,5,11,14-tetraaza-tricyclo[14.3.1.0^5,9]icosa-1⁽²⁰⁾,16,18-trien-12-yl)-butyl]-carbamic acid benzyl ester 

Relevant academic research and scientific papers

A convenient synthetic route to macrocyclic cis-3-phenylproline derivatives as mimics of Sandostatin

Enantiomerically pure 14- and 20-membered cyclic proline derivatives 2a- d were conveniently prepared from cis-3-phenylproline using macrolactonisation or macrolactamisation reactions.