479630-66-5

Upstream product

• 13674-16-3 methyl 2-hydroxy-3-phenylpropanoate 
• 407-25-0 trifluoroacetic anhydride 
• 828-01-3 phenyllactic acid 
• 358-23-6 trifluoromethylsulfonic anhydride 

Downstream Products

• 877379-64-1 methyl 3-phenyl-2-{[6-(5-phenyl-1H-pyrrol-2-yl)-2-naphthyl]oxy}propanoate 
• 877378-93-3 methyl 2-({6-[2-(1-benzyl-1H-indol-3-yl)-1,3-oxazoI-5-yl]-2-naphthyl}oxy)-3-phenylpropanoate 
• 877379-02-7 methyl 2-({6-[2-(1-methyl-1H-indol-3-yl)-1,3-oxazol-5-yl]-2-naphthyl}oxy)-3-phenylpropanoate 
• 926025-06-1 2-(5-nitro-indol-1-yl)-3-phenyl-propionic acid methyl ester 
• 1445961-68-1 2-{4-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]-2-oxo-1,2-dihydropyridin-1-yl}-3-phenylpropanoic acid 
• 848853-47-4 methyl 2-[(3-bromo-4'-{[[(2-butyl-1-benzofuran-3-yl)carbonyl](methyl)-amino]methyl}-1,1'-biphenyl-4-yl)oxy]-3-phenylpropanoate 
• 221525-83-3 (S)-6-Benzyloxycarbonylamino-2-[((2S,3S)-1-{(S)-2-[3-(tert-butoxycarbonylamino-methyl)-phenylamino]-3-phenyl-propionyl}-3-phenyl-pyrrolidine-2-carbonyl)-amino]-hexanoic acid methyl ester 
• 221525-91-3 (S)-6-Benzyloxycarbonylamino-2-[((2S,3S)-1-{(S)-2-[3-(tert-butoxycarbonylamino-methyl)-phenylamino]-3-phenyl-propionyl}-3-phenyl-pyrrolidine-2-carbonyl)-amino]-hexanoic acid 
• 221526-03-0 [4-((3S,8S,9S,12S)-3-Benzyl-4,10,13-trioxo-8-phenyl-2,5,11,14-tetraaza-tricyclo[14.3.1.0^5,9]icosa-1⁽²⁰⁾,16,18-trien-12-yl)-butyl]-carbamic acid benzyl ester 
• 221525-75-3 (S)-2-[3-(tert-Butoxycarbonylamino-methyl)-phenylamino]-3-phenyl-propionic acid 

Relevant academic research and scientific papers

PYRIDONE OR PYRIMIDONE DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

Provided is a pyridone or pyrimidone derivative(s) represented by general formula (I) and its preparation method and use. Substituents of the compound of general formula (I) are defined the same as in the specification.

Substituted indoles and methods of their use

The present invention relates generally to substituted indoles and methods of using them.

Thiazolo-naphthyl acids

The present invention relates to thiazolo-naphthyl acids of the formula and methods of using them to modulate PAI-1 expression and to treat PAI-1 related disorders.

BIPHENYLOXY-ACIDS

The present invention relates generally to substituted biphenyloxy acids (such as 4'-aryl-amido-biphenyl--4(3)-yloxy-acids and 4’-aryl-amidomethyl-biphenyl-4(3)-yloxy-acids) and methods of using them.

6-(Aryl-amido or aryl-amidomethyl)-naphthalen-2-yloxy-acidic derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1)

This invention provides novel compounds, pharmaceutical compositions and methods of treating thrombotic disorders in mammals, the compounds having the formula: Wherein: Ar is phenyl, naphthyl, furanyl, benzofuranyl, indolyl, pyrazolyl, oxazolyl, fluorenyl, phenylcycloalkane where the cycloalkane can be cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl and Ar can be optionally substituted by 1 to 3 groups selected from C1-C6 alkyl, C1-C6 alkoxy, hydroxy, phenyl-(CH2)0-6—, phenyl-(CH2)0-6O—, C3-C6 cycloalkyl, —(CH2)—C3-C6 cycloalkyl, halogen, C1-C3 perflouroalkyl and C1-C3 perfluoroalkoxy where phenyl can be substituted with from 1 to 3 groups selected from C1-C6 alkyl, C1-C6 alkoxy, phenyl, halogen, trifluoromethyl or trifluoromethoxy; R1 is hydrogen, C1-C6 alkyl or phenyl-(CH2)1-6— where phenyl can be substituted with C1-C6 alkyl, C1-C6 alkoxy, halo, trifluoromethyl or trifluoromethoxy; R2 and R3 are H, C1-C6 alkyl, phenyl-(CH2)0-3—, halo and C1-C3 perfluoroalkyl where phenyl can be substituted with C1-C6 alkyl, C1-C6 alkoxy, halo, trifluoromethyl or trifluoromethoxy; R4 is —CHR5CO2H or —CH2-tetrazole where R5 is H or benzyl; and n=0 or 1; or a pharmaceutically acceptable salt or ester form thereof.