221526-66-5

Upstream product

• 5680-80-8 methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride 
• 98-09-9 benzenesulfonyl chloride 
• 2788-84-3 (S)-serine methyl ester 

Downstream Products

• 221526-67-6 methyl (4S)-3-benzenesulfonyl-2,2-dimethyloxazolidine-4-carboxylate 
• 637773-08-1 (S)-3-Benzenesulfonyl-2,2-dimethyl-oxazolidine-4-carboxylic acid 
• 221526-54-1 N-((1S,6S,10S,13R)-3-Benzenesulfonyl-2,8-dioxo-11-oxa-3-aza-tricyclo[8.4.0.0^1,6]tetradec-13-yl)-benzenesulfonamide 
• 221526-53-0 (4aS,7aS,9R,10aS)-2,8-Bis-benzenesulfonyl-9-hydroxymethyl-octahydro-pyrrolo[2,3-i]isoquinoline-1,6-dione 
• 221526-56-3 (4aR,7aR,9R,10aR)-2,8-Bis-benzenesulfonyl-9-hydroxymethyl-octahydro-pyrrolo[2,3-i]isoquinoline-1,6-dione 
• 221526-60-9 C₃₆H₄₄N₂O₆SSi 
• 244074-49-5 3,9-bis-benzenesulfonyl-2-(tert-butyl-diphenyl-silanyloxymethyl)-octahydro-3,9-diaza-cyclopenta[d]naphthalene-5,10-dione 
• 221526-59-6 C₄₂H₄₈N₂O₈S₂Si 
• 5183-78-8 methyl(phenylsulfonyl)amide 
• 436843-88-8 methyl (2S)-2-[[(5-bromo-2-phenyl-1,3-oxazol-4-yl)methyl](phenylsulfonyl)amino]-3-{[tert-butyl(dimethyl)silyl]oxy}propanoate 
• 436843-90-2 (6S,7R)-6-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-phenyl-5-(phenylsulfonyl)4,5,6,7-tetrahydro[1,3]oxazolo[4,5-c]pyridin-7-ol 
• 436843-89-9 (6S)-6-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-phenyl-5-(phenylsulfonyl)-5,6-dihydro[1,3]oxazolo[4,5-c]pyridin-7(4H)-one 

Relevant academic research and scientific papers

Halofluorination of N-protected α,β-dehydro-α-amino acid esters—A convenient synthesis of α-fluoro-α-amino acid derivatives

N-protected dehydroamino acid methyl esters have been converted to α-fluoro-β-halo amino acid derivatives under halofluorination reaction conditions. The influences of the nitrogen protecting group of the substrates and of the halonium electrophile on the reaction outcome and the stability of the obtained products have been studied. Furthermore, reduction of the halogen substituent (Cl or Br) under radical conditions provided a possibility for follow-up reactions. Nucleophilic substitution reactions, however, failed.

IMIDAZOLIDINONE DERIVATIVES

The invention is concerned with novel imidazolidinone derivatives of formula (I): wherein R1 to R11 and X are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds bind

Practical synthesis of a 3, 4, 4a, 5, 8, 8a-hexahydro-2H-isoquinoline-1, 6-dione ring system by the Diels-Alder reaction of an optically active dienophile, a 5, 6-dihydro-1H-pyridin-2-one derivative, with siloxydiene

An efficient method for preparing chiral 3-substituted-5, 6-dihydro-1H-pyridin-2-one (1) in large scale, based on a modification of our previous method, is described. The large scale Diels-Alder reaction of 1 with siloxydiene (2) to synthesize hexahydrois

An efficient access to the optically active manzamine tetracyclic ring system

The highly stereoselective synthesis of the optically active tetracyclic core 2 of Manzamine A 1 was achieved via the Diels-Alder reaction of dihydropyridinone 12b, derived from L-serine, with siloxydienes, followed by sequential new and conventional pathways.