221527-77-1

Basic information

• Product Name: Benzene, 1-[(1E)-3-chloro-1-propenyl]-4-(trifluoromethyl)-
• CAS NO: 221527-77-1
• Molecular Formula: C10H8ClF3
• Molecular Weight: 220.622
• Mol File: 221527-77-1.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzene, 1-[(1E)-3-chloro-1-propenyl]-4-(trifluoromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-[(1E)-3-chloro-1-propenyl]-4-(trifluoromethyl)-(221527-77-1)
• EPA Substance Registry System: Benzene, 1-[(1E)-3-chloro-1-propenyl]-4-(trifluoromethyl)-(221527-77-1)

Safety Data

• Hazardous Substances Data: 221527-77-1(Hazardous Substances Data)

Upstream product

• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 149946-79-2 1-(4'-(trifluoromethyl)phenyl)-allylalcohol 
• 455-13-0 4-Iodobenzotrifluoride 
• 95123-61-8 (2E)-3-(4-trifluoromethylphenyl)prop-2-enal 
• 105919-36-6 trans-4-(trifluoromethyl)cinnamoyl chloride 
• 2062-26-2 3-<4'-(trifluoromethyl)phenyl>-2-propenoic acid 
• 125617-18-7 3-(4-trifluoromethylphenyl)-2-propen-1-ol 

Downstream Products

• 716316-92-6 2-propargyl-2-[trans-4-(trifluoromethyl)cinnamyl]malonic acid diethyl ester 
• 1314581-21-9 (E)-1,2,3,4,5-pentafluoro-6-(3-(4-(trifluoromethyl)phenyl)allyl) benzene 
• 1464149-45-8 (E)-(trifluoromethyl)(3-(4-(trifluoromethyl)phenyl)allyl)sulfane 
• 1616917-78-2 (E)-4-(3-(4-(trifluoromethyl)phenyl)allyl)phenol 
• 1616917-69-1 (E)-4,4,5,5-tetramethyl-2-(4-((3-(4-(trifluoromethyl)phenyl)allyl)oxy)phenyl)-1,3,2-dioxaborolane 
• 1443128-88-8 tert-butyl (E)-2-diazo-5-(4-(trifluoromethyl)phenyl)pent-4-enoate 
• 1443129-00-7 tert-butyl (1S,2S,3R)-2-(4-(trifluoromethyl)phenyl)bicyclo[1.1.0]butane-1-carboxylate 
• 1443129-38-1 C₁₈H₂₁F₃O₃ 
• 1427549-12-9 (S)-4,4,5,5-tetramethyl-2-(4-(4-(trifluoromethyl)phenyl)hexa-1,5-dien-2-yl)-1,3,2-dioxaborolane 
• 1427549-53-8 (E)-4,4,5,5-tetramethyl-2-(6-(4-(trifluoromethyl)phenyl)hexa-1,5-dien-2-yl)-1,3,2-dioxaborolane 
• 1237786-77-4 (S)-1-(hexa-1,5-dien-3-yl)-4-(trifluoromethyl)benzene 

Relevant articles and documents

Lanthanide-Catalyzed Tandem Addition of Amines to Cyanoalkenes: Synthesis of Cyclic Amidines

A tandem insertion of aliphatic nitriles and unactivated alkenes to the N-H bond of secondary aliphatic amines catalyzed by simple trialkyl rare-earth metal complexes was disclosed. This reaction provides a highly atom-economic and stereoselective way to a range of cyclic amidines under mild reaction conditions.

Palladium-catalyzed oxidative arylacetoxylation of alkenes: Synthesis of indole and indoline derivatives

A method for the oxidative arylacetoxylation of alkenes has been developed to synthesize indole and indoline derivatives from readily accessible substrates. The cinnamyl tethered anilines with picolinamide as a directing group provided 3-substituted indoles via intramolecular oxidative arylacetoxylation, and the 2-methyl substituted cinnamyl anilines furnished indoline derivatives with 3-position quaternary stereocenters in good to excellent yields via sequential intramolecular oxidative arylacetoxylation, hydrolysis and oxidation steps.

Catalytic enantioselective allyl-allyl cross-coupling with a borylated allylboronate

Catalytic enantioselective allyl-allyl cross-coupling of a borylated allylboronate reagent gives versatile borylated chiral 1,5-hexadienes. These compounds may be manipulated in a number of useful ways to give functionalized chiral building blocks for asymmetric synthesis.