149946-79-2

Basic information

• Product Name: Benzenemethanol, a-ethenyl-4-(trifluoromethyl)-
• CAS NO: 149946-79-2
• Molecular Formula: C10H9F3O
• Molecular Weight: 202.176
• Mol File: 149946-79-2.mol
• Article Data: 48

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, a-ethenyl-4-(trifluoromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, a-ethenyl-4-(trifluoromethyl)-(149946-79-2)
• EPA Substance Registry System: Benzenemethanol, a-ethenyl-4-(trifluoromethyl)-(149946-79-2)

Safety Data

• Hazardous Substances Data: 149946-79-2(Hazardous Substances Data)

Upstream product

• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 3536-96-7 vinylmagnesium chloride 
• 1826-67-1 vinyl magnesium bromide 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 107-02-8 acrolein 
• 402-51-7 4-(trifluoromethyl)phenylmagnesium bromide 

Downstream Products

• 169172-22-9 3-acetoxy-3-(4-(trifluoromethyl)phenyl)-1-propene 
• 711-33-1 4-trifluoromethyl propiophenone 
• 1169852-25-8 (E)-tert-butyl (3-(4-(trifluoromethyl)phenyl)allyl)carbamate 
• 898769-04-5 3-p-tolyl-1-(4-(trifluoromethyl)phenyl)propan-1-one 
• 782462-82-2 (R)-1-(but-3-en-2-yl)-4-(trifluoromethyl)benzene 
• 782462-82-2 (S)-1-(but-3-en-2-yl)-4-(trifluoromethyl)benzene 
• 1372719-85-1 1-(4-methylpent-1-en-3-yl)-4-(trifluoromethyl)benzene 
• 67081-98-5 (S)-1-(4-(trifluoromethyl)phenyl)propan-1-ol 
• 67081-98-5 (R)-1-(4-(trifluoromethyl)phenyl)propan-1-ol 
• 1204403-50-8 1-(hexa-1,5-dien-3-yl)-4-(trifluoromethyl)benzene 

Relevant articles and documents

Catalytic Asymmetric Intramolecular Bromolactonization of α,β-Unsaturated Ketones

Enantioselective bromolactonization by using an amino-urea catalyst to generate the important bromo-containing 3,4-dihydroisocoumarins is described. Excellent yields and good enantioselectivities could be achieved for various 3,4-dihydroisocoumarin compou

Lanthanide-Catalyzed Tandem Addition of Amines to Cyanoalkenes: Synthesis of Cyclic Amidines

A tandem insertion of aliphatic nitriles and unactivated alkenes to the N-H bond of secondary aliphatic amines catalyzed by simple trialkyl rare-earth metal complexes was disclosed. This reaction provides a highly atom-economic and stereoselective way to a range of cyclic amidines under mild reaction conditions.

Enantioselective Allylation of Alkenyl Boronates Promotes a 1,2-Metalate Rearrangement with 1,3-Diastereocontrol

Alkenyl boronates add to Ir(π-allyl) intermediates with high enantioselectivity. A 1,2-metalate shift forms a second C-C bond and sets a 1,3-stereochemical relationship. The three-component coupling provides tertiary boronic esters that can undergo multiple additional functionalizations. An extension to trisubstituted olefins sets three contiguous stereocenters.

Pd-Catalyzed Asymmetric Acyl-Carbamoylation of an Alkene to Construct an α-Quaternary Chiral Cycloketone

Herein, we report the palladium-catalyzed asymmetric acyl-carbamoylation of an alkene by employing thioesters as the acyl electrophiles and t-BuNC as the carbamoyl reagent, affording an α-quaternary chiral cycloketone in synthetically useful yields with excellent enantioselectivity. The reaction proceeded via asymmetric 1,2-migratory insertions of acyl-Pd into alkenes and subsequent migratory insertion of isocyanides into C(sp3)-PdII. The product could be diversified to some valuable skeletons with retention of enantiopurity, demonstrating the synthetic utility of this protocol.