22157-27-3

Upstream product

• 141-97-9 ethyl acetoacetate 
• 149-73-5 trimethyl orthoformate 
• 64-17-5 ethanol 
• 121781-82-6 5-(1-methoxyethylene) Meldrum's acid 
• 77-78-1 dimethyl sulfate 
• 67-56-1 methanol 
• 66279-50-3 ethylacetoacetate, K(+) salt 
• 80-48-8 methyl p-toluene sulfonate 
• 186581-53-3 diazomethane 

Downstream Products

• 112165-31-8 5-(4-bromophenyl)-5-methyl 3-methoxy-(2E,4Z)-pentadienoic acid 
• 112165-28-3 5-(4-bromophenyl)-5-methyl 3-methoxy-(2E,4E)-pentadienoic acid 
• 69813-36-1 3-methoxy-5-phenyl-2(E),4(E)-pentadienoic acid 
• 112330-95-7 (2E,4E)-5-(3,4-Dimethoxy-phenyl)-3-methoxy-penta-2,4-dienoic acid 
• 112165-29-4 5-phenyl-5-methyl 3-methoxy-(2E,4Z)-pentadienoic acid 
• 112165-26-1 5-phenyl-5-methyl 3-methoxy-(2E,4E)-pentadienoic acid 
• 112165-30-7 5-(4-methylphenyl)-5-methyl 3-methoxy-(2E,4Z)-pentadienoic acid 
• 112165-27-2 5-(4-methylphenyl)-5-methyl 3-methoxy-(2E,4E)-pentadienoic acid 
• 67107-76-0 3-methoxy-2-butenoic acid 
• 561276-74-2 (+)-(E,R_S)-1-(p-tolylsulfinyl)-4-methoxy-3-pentene-2-one 
• 561276-76-4 (E,2S,R_S)-1-(p-tolylsulfinyl)-4-methoxy-3-pentene-2-ol 
• 112330-99-1 4-Methoxy-2-phenyl-cyclopenta-2,4-dienone 
• 112331-00-7 2-(2,6-Dichloro-phenyl)-4-methoxy-cyclopenta-2,4-dienone 
• 67107-76-0 (E)-β-methoxymethacrylic acid 

Relevant academic research and scientific papers

PANTETHEINE DERIVATIVES AND USES THEREOF

The present disclosure relates to compounds of Formula (I), (II), or (II'): (I), (II), (II'), and pharmaceutically acceptable salts or solvates thereof. The present disclosure also relates to pharmaceutical compositions comprising the compounds and therapeutic and diagnostic uses of the compounds and pharmaceutical compositions.

Preparation of some alkenoic acid derivatives as new plant growth regulators

A number of 3-alkoxy-5-substituted-2,4-alkadienoic acids (4a-f) have been synthesized from the reaction of ethyl (E)-3-alkoxy-2-butenoate with different ketones in the presence of KOH in DMSO. Similarly, several (2Z,4E)-5-[4-(benzylthio)phenyl]-3-alkoxyhe

Iron(III) tosylate in the preparation of dimethyl and diethyl acetals from ketones and β-keto enol ethers from cyclic β-diketones

An efficient method for conversion of ketones to their corresponding dimethyl and diethyl acetals and of cyclic β-diketones into β-keto enol ethers using Fe(OTs)3 as a catalyst is described. Copyright Taylor & Francis Group, LLC.

Iridium-catalyzed asymmetric hydrogenation of vinyl ethers

A carbene-oxazoline catalyst 1 proved to be an effective catalyst for reduction of an enol ether that the literature suggested could not be hydrogenated effectively by P,N-Ir catalysts. Thus, a series of ester and alcohol substrates were hydrogenated using catalyst 1. Good to excellent enantioselectivities and high conversions were obtained.

New insights into the reduction of β,δ-diketo-sulfoxides

New developments in the reduction of β,δ-diketo-sulfoxides, a reaction that affords important key intermediates for total synthesis, are described. We showed without ambiguity using NMR experiments, that the β-carbonyl group is totally enolised. This result is inconsistent with the previous hypothesis, which supposed the other tautomer (enolisation at the δ-position) as the major one. We propose a rationale to explain the side reactions occurring during the reduction of unprotected β,δ-diketo-sulfoxides and showed that judicious protection of the δ-carbonyl group gave all diastereoisomers of β-hydroxy-δ-ketosulfoxides.

Carboxy(vinyl)ketene intermediates in the thermolysis of methylthio- and methoxy-substituted Meldrum's acid derivatives

Methylthio- and methoxy-substituted carboxy(vinyl)ketenes 10 and 16a have been identified by Ar matrix isolation FTIR spectroscopy following flash vacuum thermolysis (FVT) of Meldrum's acid derivatives 7 and 13a. Methylthio(methyl)methyleneketene 9 and alkoxy(methyl)methyleneketene 15 are formed concurrently at high FVT temperatures. The alkoxy(methyl)methyleneketenes 15 do not isomerise to alkoxy(vinyl)ketenes 18, which have been generated and identified in other reactions. Ethoxy(methyl)-methyleneketene 15b readily eliminates ethene in a retro-ene type reaction to produce acetylketene 22. Ketenes 15 react with alcohols and amines to produce 3-alkoxybutenoic acid derivatives 21.

Reaction of Ethyl (E)-3-Methoxy-2-butenoate with Some Substituted Aromatic Aldehydes: Synthesis of 5-Aryl-3-Methoxy-(2E,4E)-2,4-Pentadienoic Acids

The reaction between ethyl (E)-3-methoxy-2-butenoate (1) and some substituted benzaldehydes 2 in the presence of sodium hydride leads to 5-aryl-3-methoxy-(2E,4E)-2,4-pentadienoic acids 3.The UV, IR and (1)H- and (13)C-NMR spectral data for the compounds s

RETINOIDE-II : DARSTELLUNG VON 13-METHOXYRETINAL

9-trans-13-cis-(7a) and 9-cis-13-cis-13-Methoxyretinal (7b) have been prepared from the C15-aldehyde 5 and the E-phosphonate 4 by Wittig-Horner reaction.