22157-27-3

Basic information

• Product Name: 2-Butenoic acid,3-methoxy-, ethyl ester, (2E)-
• Synonyms: 2-Butenoicacid, 3-methoxy-, ethyl ester, (E)-; Crotonic acid, 3-methoxy-, ethyl ester,(E)- (8CI); (2E)-3-Methoxybut-2-enoic acid ethyl ester; Ethyl(E)-3-methoxy-2-butenoate; Ethyl (E)-3-methoxycrotonate; Methyl (E)-b-methoxymethacrylate; NSC 165534
• CAS NO: 22157-27-3
• Molecular Formula: C₇H₁₂O₃
• Molecular Weight: 144.1684
• Mol File: 22157-27-3.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 188.6°Cat760mmHg
• Flash Point: 69.3°C
• Density: 0.978g/cm³
• CAS DataBase Reference: 2-Butenoic acid,3-methoxy-, ethyl ester, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butenoic acid,3-methoxy-, ethyl ester, (2E)-(22157-27-3)
• EPA Substance Registry System: 2-Butenoic acid,3-methoxy-, ethyl ester, (2E)-(22157-27-3)

Safety Data

• Hazardous Substances Data: 22157-27-3(Hazardous Substances Data)

Upstream product

• 141-97-9 ethyl acetoacetate 
• 149-73-5 trimethyl orthoformate 
• 67-56-1 methanol 
• 77-78-1 dimethyl sulfate 
• 64-17-5 ethanol 
• 121781-82-6 5-(1-methoxyethylene) Meldrum's acid 
• 66279-50-3 ethylacetoacetate, K(+) salt 
• 80-48-8 methyl p-toluene sulfonate 
• 186581-53-3 diazomethane 

Downstream Products

• 69813-36-1 3-methoxy-5-phenyl-2(E),4(E)-pentadienoic acid 
• 112330-94-6 (2E,4E)-3-Methoxy-5-(4-methoxy-phenyl)-penta-2,4-dienoic acid 
• 112330-95-7 (2E,4E)-5-(3,4-Dimethoxy-phenyl)-3-methoxy-penta-2,4-dienoic acid 
• 112330-98-0 (2E,4E)-5-(3,4-Dichloro-phenyl)-3-methoxy-penta-2,4-dienoic acid 
• 75668-75-6 N-(1-Ethoxycarbonyl-2-methoxy-2-propenylsulfinyl)-p-toluolsulfonamid 
• 67107-76-0 (E)-β-methoxymethacrylic acid 
• 561276-76-4 (E,2S,R_S)-1-(p-tolylsulfinyl)-4-methoxy-3-pentene-2-ol 
• 561276-74-2 (+)-(E,R_S)-1-(p-tolylsulfinyl)-4-methoxy-3-pentene-2-one 
• 112165-30-7 5-(4-methylphenyl)-5-methyl 3-methoxy-(2E,4Z)-pentadienoic acid 
• 112165-27-2 5-(4-methylphenyl)-5-methyl 3-methoxy-(2E,4E)-pentadienoic acid 
• 112165-29-4 5-phenyl-5-methyl 3-methoxy-(2E,4Z)-pentadienoic acid 
• 112165-26-1 5-phenyl-5-methyl 3-methoxy-(2E,4E)-pentadienoic acid 
• 112331-01-8 (2E,4E)-5-(2,6-Dichloro-phenyl)-3-methoxy-penta-2,4-dienoic acid 
• 112165-31-8 5-(4-bromophenyl)-5-methyl 3-methoxy-(2E,4Z)-pentadienoic acid 

Relevant articles and documents

PANTETHEINE DERIVATIVES AND USES THEREOF

The present disclosure relates to compounds of Formula (I), (II), or (II'): (I), (II), (II'), and pharmaceutically acceptable salts or solvates thereof. The present disclosure also relates to pharmaceutical compositions comprising the compounds and therapeutic and diagnostic uses of the compounds and pharmaceutical compositions.

Iron(III) tosylate in the preparation of dimethyl and diethyl acetals from ketones and β-keto enol ethers from cyclic β-diketones

An efficient method for conversion of ketones to their corresponding dimethyl and diethyl acetals and of cyclic β-diketones into β-keto enol ethers using Fe(OTs)3 as a catalyst is described. Copyright Taylor & Francis Group, LLC.

New insights into the reduction of β,δ-diketo-sulfoxides

New developments in the reduction of β,δ-diketo-sulfoxides, a reaction that affords important key intermediates for total synthesis, are described. We showed without ambiguity using NMR experiments, that the β-carbonyl group is totally enolised. This result is inconsistent with the previous hypothesis, which supposed the other tautomer (enolisation at the δ-position) as the major one. We propose a rationale to explain the side reactions occurring during the reduction of unprotected β,δ-diketo-sulfoxides and showed that judicious protection of the δ-carbonyl group gave all diastereoisomers of β-hydroxy-δ-ketosulfoxides.