22161-42-8

Basic information

• Product Name: trans-4-Methyl-α-phenyl-zimtsaeure
• CAS NO: 22161-42-8
• Molecular Weight: 238.286
• Mol File: 22161-42-8.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: trans-4-Methyl-α-phenyl-zimtsaeure(CAS DataBase Reference)
• NIST Chemistry Reference: trans-4-Methyl-α-phenyl-zimtsaeure(22161-42-8)
• EPA Substance Registry System: trans-4-Methyl-α-phenyl-zimtsaeure(22161-42-8)

Safety Data

• Hazardous Substances Data: 22161-42-8(Hazardous Substances Data)

Upstream product

• 103-82-2 phenylacetic acid 
• 104-87-0 4-methyl-benzaldehyde 
• 124-38-9 carbon dioxide 
• 3287-02-3 4-(phenylethynyl)toluene 
• 6262-58-4 Phenyl-p-tolyl-cyclopropenon 
• 17556-67-1 isopropyl-[(4-methylphenyl)meth-(E)ylidene]amine 

Downstream Products

• 1142935-03-2 (2S)-3-(4-methylphenyl)-2-phenylpropanoic acid 
• 1657-45-0 (Z)-4-methylstilbene 

Relevant articles and documents

Palladium-Catalyzed Highly Regioselective Hydrocarboxylation of Alkynes with Carbon Dioxide

A Pd-catalyzed highly regioselective hydrocarboxylation of alkynes with carbon dioxide has been established. By the combination of Pd(PPh3)4 and 2,2′-bis(diphenylphosphino)-1,1′-binaphthalene (binap), a variety of functionalized alkynes, including aryl alkynes, aliphatic alkynes, propargylamines, and propargyl ethers, could be leveraged to provide a wide array of α-acrylic acids in high yields with high regioselectivity under mild reaction conditions. Experimental and DFT mechanistic studies revealed that this reaction proceeded via the cyclopalladation process of alkynes and carbon dioxide in the presence of binap to generate a five-membered palladalactone intermediate and enabled the formation of Markovnikov adducts. Moreover, this strategy provided an effective method for the late-stage functionalization of alkyne-containing complicated molecules, including natural products and pharmaceuticals.

Pathways for the solvent-free condensation between schiff bases and methylenic compounds

Pathways for the solvent-free condensation between Schiff Bases and methylenic compounds are discussed taking into account the reported mechanistic purposes and new experimental data.

N-SUBSTITUTED HETEROCYCLIC DERIVATIVES USEFUL IN THE TREATMENT OF CARDIOVASCULAR DISORDERS

The present invention relates to N-substituted heterocyclic derivatives of formula: STR1 processes for their preparation, and pharmaceutical compositions which contain them. The compounds according to the invention are non-peptide compounds which oppose the action of angiotensin II. The compounds according to the invention are thus useful in the treatment of cardiovascular disorders such as hypertension and heart failure.