221616-80-4

Basic information

• Product Name: 5-fluoro-1-<5-O-(tert-butyldimethylsilyl)-2,3-dideoxy-2-fluoro-α-L-glycero-pent-2-enofuranosyl>-N⁴-benzoylcytosine
• Synonyms: 5-fluoro-1-<5-O-(tert-butyldimethylsilyl)-2,3-dideoxy-2-fluoro-α-L-glycero-pent-2-enofuranosyl>-N⁴-benzoylcytosine
• CAS NO: 221616-80-4
• Molecular Weight: 463.556
• Mol File: 221616-80-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-fluoro-1-<5-O-(tert-butyldimethylsilyl)-2,3-dideoxy-2-fluoro-α-L-glycero-pent-2-enofuranosyl>-N⁴-benzoylcytosine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-fluoro-1-<5-O-(tert-butyldimethylsilyl)-2,3-dideoxy-2-fluoro-α-L-glycero-pent-2-enofuranosyl>-N⁴-benzoylcytosine(221616-80-4)
• EPA Substance Registry System: 5-fluoro-1-<5-O-(tert-butyldimethylsilyl)-2,3-dideoxy-2-fluoro-α-L-glycero-pent-2-enofuranosyl>-N⁴-benzoylcytosine(221616-80-4)

Safety Data

• Hazardous Substances Data: 221616-80-4(Hazardous Substances Data)

Upstream product

• 210474-45-6 (R)-(+)-4-<(tert-butyldimethylsilyloxy)methyl>-2-fluoro-2-buten-4-olide 
• 221616-72-4 (R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-3-fluoro-2,5-dihydro-furan-2-ol 
• 221616-69-9 (E)/(Z)-ethyl 3-<(R)-2,2-dimethyl-1,3-dioxolan-4-yl>-2-fluoroacrylate 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 10357-07-0 N-benzoyl-5-fluorocytosine 
• 210474-50-3 1-acetyl-4-<(tert-butyldimethylsilyloxy)methyl>-2-fluoro-2-buten-4-olide 

Downstream Products

• 181785-91-1 5-fluoro-1-(2,3-dideoxy-2-fluoro-α-L-glycero-pent-2-enofuranosyl)cytosine 
• 221616-88-2 5-fluoro-1-(2,3-dideoxy-2-fluoro-α-L-glycero-pent-2-enofuranosyl)-N⁴-benzoylcytosine 

Relevant articles and documents

Synthesis and anti-HIV and anti-HBV activities of 2'-fluoro-2',3'- unsaturated L-nucleosides

The synthesis of L-nucleoside analogues containing 2'-vinylic fluoride was accomplished by direct condensation method, and their anti-HIV and anti- HBV activities were evaluated in vitro. The key intermediate 8, the sugar moiety of our target compounds, w