221617-20-5

Upstream product

• 69048-76-6 6-iodo-1,3-benzodioxole-5-methanol 
• 495-76-1 piperonol 
• 153254-99-0 5-(bromomethyl)-6-iodobenzo[d][1,3]dioxole 

Downstream Products

• 52886-06-3 hippadine 
• 40360-71-2 anhydrolycorine-7-one 
• 221617-23-8 N-[2-(cyclohex-2-enyl)ethyl]-6-iodo-1,3-benzodioxole-5-methanamine 
• 221617-24-9 N-chloro-N-[2-(cyclohex-2-enyl)ethyl]-6-iodo-1,3-benzodioxole-5-methanamine 

Relevant academic research and scientific papers

Transition metal complexes in organic synthesis, part 69. Total synthesis of the Amaryllidaceae alkaloids anhydrolycorinone and hippadine using iron-and palladium-mediated coupling reactions

A novel synthesis of the Amaryllidaceae alkaloids anhydrolycorinone and hippadine has been developed using an iron-mediated oxidative alkylamine cyclization and an intramolecular palladium-mediated biaryl coupling as the key steps.

Radical cyclizations. A convergent total synthesis of (±)-γ-Lycorane

(±)-γ-Lycorane has been synthesized in 10 steps from piperonylic alcohol. Two radical reactions were used successively to build the D and B rings.

Radical cyclizations - Synthesis of γ-lycorane

(+)-γ-Lycorane has been synthesized in ten steps from piperonylic alcohol. Two radical reactions were used successively to build the D and B rings. A formal synthesis of (+)-γ-lycorane was achieved via an optically active unsaturated aldehyde intermediate