52886-06-3

Basic information

• Product Name: hippadine
• Synonyms: hippadine
• CAS NO: 52886-06-3
• Molecular Formula: C16H9NO3
• Molecular Weight: 263.251
• Mol File: 52886-06-3.mol
• Article Data: 26

Chemical Properties

• Boiling Point: 422.1°Cat760mmHg
• Flash Point: 209.1°C
• Appearance: /
• Density: 1.56g/cm³
• Vapor Pressure: 2.48E-07mmHg at 25°C
• Refractive Index: 1.785
• CAS DataBase Reference: hippadine(CAS DataBase Reference)
• NIST Chemistry Reference: hippadine(52886-06-3)
• EPA Substance Registry System: hippadine(52886-06-3)

Safety Data

• Hazardous Substances Data: 52886-06-3(Hazardous Substances Data)

Usage

General Description

Hippadine is a chemical compound that belongs to the class of organic compounds known as phenylpiperidines. It is a synthetic analog of the natural compound piperidine and is used as an antihistamine and a cough suppressant. Hippadine works by blocking the action of histamine, a substance in the body that causes allergic symptoms and coughing. It is commonly used to relieve symptoms of allergies, such as sneezing, itching, and runny nose, as well as to suppress coughing caused by respiratory infections. Hippadine is available in various forms, including tablets, syrups, and injectable solutions, and is typically taken orally. Like all medications, hippadine may cause side effects such as drowsiness, dizziness, and dry mouth, and should be used with caution, especially in combination with other sedating drugs.

InChI:InChI=1/C16H9NO3/c18-16-12-7-14-13(19-8-20-14)6-11(12)10-3-1-2-9-4-5-17(16)15(9)10/h1-7H,8H2

Upstream product

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Downstream Products

• 88660-12-2 pratorimine 

Relevant articles and documents

Metal-free directed sp 2-C–H borylation

Organoboron reagents are important synthetic intermediates that have a key role in the construction of natural products, pharmaceuticals and organic materials1. The discovery of simpler, milder and more efficient approaches to organoborons can

Synthesis of pyrrolophenanthridine alkaloids based on C(sp3)-H and C(sp2)-H functionalization reactions

Assoanine, pratosine, hippadine, and dehydroanhydrolycorine belong to the pyrrolophenanthridine family of alkaloids, which are isolated from plants of the Amaryllidaceae species. Structurally, these alkaloids are characterized by a tetracyclic skeleton that contains a biaryl moiety and an indole core, and compounds belonging to this class have received considerable interest from researchers in a number of fields because of their biological properties and the challenges associated with their synthesis. Herein, a strategy for the total synthesis of these alkaloids by using C-H activation chemistry is described. The tetracyclic skeleton was constructed in a stepwise manner by C(sp 3)-H functionalization followed by a Catellani reaction, including C(sp2)-H functionalization. A one-pot reaction involving both C(sp3)-H and C(sp2)-H functionalization was also attempted. This newly developed strategy is suitable for the facile preparation of various analogues because it uses simple starting materials and does not require protecting groups.

Construction of pyrrolophenanthridinone scaffolds mediated by samarium(II) diiodide and access to natural product synthesis

Pyrrolophenanthridinone derivatives including the natural products were readily synthesized by samarium(II)-mediated reductive cyclization of aryl radical onto a benzene ring under mild reaction conditions. This methodology was applied to the concise synt