221632-75-3

Basic information

• Product Name: 3-hydroxy-3-(pyridin-3-yl)-5-methoxy-2-phenyl-2,3-dihydro-1H-isoindol-1-one
• CAS NO: 221632-75-3
• Molecular Weight: 332.359
• Mol File: 221632-75-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-hydroxy-3-(pyridin-3-yl)-5-methoxy-2-phenyl-2,3-dihydro-1H-isoindol-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-3-(pyridin-3-yl)-5-methoxy-2-phenyl-2,3-dihydro-1H-isoindol-1-one(221632-75-3)
• EPA Substance Registry System: 3-hydroxy-3-(pyridin-3-yl)-5-methoxy-2-phenyl-2,3-dihydro-1H-isoindol-1-one(221632-75-3)

Safety Data

• Hazardous Substances Data: 221632-75-3(Hazardous Substances Data)

Upstream product

• 93-60-7 methyl 3-pyridinecarboxylate 
• 7465-88-5 4-methoxy-N-phenylbenzamide 

Relevant articles and documents

Application of organolithium and related reagents in synthesis. Part 221. Synthetic strategies based on ortho-aromatic metallation. A concise regiospecific conversion of benzoic acids into the 4-pyridyl-2h-phthalazin- 1-ones

The synthesis of phthalazin-1-ones 6, 7, 8 via the reaction of 3- hydroxyisoindolin-1-ones 3, 4, 5 with hydrazine hydrate is described. Starting compounds 3, 4, 5 were regiospecifically prepared upon the lithiation (n-BuLi) of the benzanilides 1 and subsequently the reaction of the dilithiated anilides 2 with methyl pyridinecarboxylates.