7465-88-5

Usage

Uses

Used in Pharmaceutical Industry:
N-Phenyl-4-methoxybenzamide is used as a chemical intermediate for the synthesis of various drugs, contributing to the development of new pharmaceuticals.
Used in Anti-inflammatory and Analgesic Applications:
N-Phenyl-4-methoxybenzamide is used as an anti-inflammatory and analgesic agent due to its reported properties, offering potential benefits in the management of pain and inflammation.
Used in Neurodegenerative Disease Treatment:
N-Phenyl-4-methoxybenzamide is studied for its potential use in the treatment of neurodegenerative diseases, suggesting a possible role in managing or treating conditions such as Alzheimer's or Parkinson's disease.
Used in Cancer Treatment:
N-Phenyl-4-methoxybenzamide is being investigated for its potential application in cancer treatment, indicating a possible contribution to oncology research and therapeutics.

InChI:InChI=1/C14H13NO2/c1-17-13-9-7-11(8-10-13)14(16)15-12-5-3-2-4-6-12/h2-10H,1H3,(H,15,16)

Upstream product

• 79-37-8 oxalyl dichloride 
• 60-29-7 diethyl ether 
• 10147-61-2 (Z)-(4-methoxyphenyl)(phenyl)methanone oxime 
• 10147-60-1 (4-methoxyphenyl)phenylmethanone oxime 
• 59101-33-6 N-benzoyl-O-(4-methoxy-benzoyl)-hydroxylamine 
• 123-11-5 4-methoxy-benzaldehyde 
• 98-95-3 nitrobenzene 
• 62-53-3 aniline 
• 103-71-9 phenyl isocyanate 
• 100-66-3 methoxybenzene 
• 100-09-4 4-methoxybenzoic acid 
• 100-07-2 4-methoxy-benzoyl chloride 
• 14271-83-1 4-methoxybenzoyl cyanide 
• 86399-73-7 N,O-bis-(4-methoxy-benzoyl)-N-phenyl-hydroxylamine 

Downstream Products

• 1151-93-5 4-(N,N-dimethylamino)-4'-methoxybenzophenone 
• 104689-69-2 (4-(diethylamino)phenyl)(4-methoxyphenyl)methanone 
• 38968-72-8 N-phenyl-(4-methoxypheny)acetimidoyl chloride 
• 5866-79-5 (4-Methoxy-benzoyl)-phenyl-carbamic acid isopropyl ester 
• 68823-22-3 2-(4-methoxy-phenyl)-4,6-dioxo-3,5-diphenyl-5,6-dihydro-4H-[1,3]oxazinium betaine 
• 154822-32-9 3-hydroxy-3-(pyridin-4-yl)-5-methoxy-2-phenyl-2,3-dihydro-1H-isoindol-1-one 
• 154822-28-3 3-hydroxy-3-(pyridin-2-yl)-5-methoxy-2-phenyl-2,3-dihydro-1H-isoindol-1-one 
• 147637-14-7 3-hydroxy-5-methoxy-2-chphenyl-2,3-dihydro-1H-isoindol-1-one 
• 28281-58-5 7-methoxyisobenzofuran-1(3H)-one 
• 100990-66-7 4-methoxy-N-(4-(4-methoxybenzamido)phenyl)-N-phenylbenzamide 
• 26060-23-1 4-methoxy-N-phenylthiobenzamide 
• 748164-68-3 3-(2'-methoxyphenyl)-5-methoxy-1-isobenzofuranone 
• 221632-75-3 3-hydroxy-3-(pyridin-3-yl)-5-methoxy-2-phenyl-2,3-dihydro-1H-isoindol-1-one 
• 259817-06-6 ethyl 2-diazo-3-[N-(4-methoxybenzoyl)-N-phenylamino]-3-oxopropanoate 

Relevant academic research and scientific papers

Cobalt-Catalyzed Deoxygenative Hydroboration of Nitro Compounds and Applications to One-Pot Synthesis of Aldimines and Amides

The commercially available and bench-stable Co(acac)2 ligated with bis[(2-diphenylphosphino)phenyl] ether (dpephos) was employed for selective room temperature hydroboration of nitro compounds with HBPin (TOF up to 4615 h?1), tolerating halide, hydroxy, amino, ether, ester, lactone, amide and heteroaromatic functionalities. These reactions offered a direct access to a variety of N-borylamines RN(H)BPin, which were in situ treated with aldehydes and carboxylic acids to produce a series of aldimines and secondary carboxamides without the need for dehydrating and/or coupling reagents. Combination of these transformations in a sequential one-pot manner allowed for direct and selective synthesis of aldimines and secondary carboxamides from readily available and inexpensive nitro compounds.

Novel Conjugated s-Tetrazine Derivatives Bearing a 4H-1,2,4-Triazole Scaffold: Synthesis and Luminescent Properties

A series of new symmetrical s-tetrazine derivatives, coupled via a 1,4-phenylene linkage with a 4H-1,2,4-triazole ring, were obtained. The combination of these two rings in an extensively coupled system has significant potential applications, mainly in op

Nickel-Catalyzed Reductive Cross-Coupling of N-Acyl and N-Sulfonyl Benzotriazoles with Diverse Nitro Compounds: Rapid Access to Amides and Sulfonamides

Herein we report a Ni-catalyzed reductive transamidation of conveniently available N-acyl benzotriazoles with alkyl, alkenyl, and aryl nitro compounds, which afforded various amides with good yields and a broad substrate scope. The same catalytic reaction conditions were also applicable for N-sulfonyl benzotriazoles, which could undergo smooth reductive coupling with nitroarenes and nitroalkanes to afford the corresponding sulfonamides.

Activated charcoal supported copper nanoparticles: A readily available and inexpensive heterogeneous catalyst for the N-arylation of primary amides and lactams with aryl iodides

A novel heterogeneous copper catalyst has been developed by supporting copper nanoparticles on activated charcoal via in situ reducing copper(II) with aqueous hydrazine as reductant. The characterization of Cu/C catalyst showed that the Cu0 nano-particles were formed on the surface of charcoal. This catalyst displayed good catalytic activities toward the N-arylation of primary amides and lactams with aryl iodides.

Regioselective Synthesis of 2° Amides Using Visible-Light-Induced Photoredox-Catalyzed Nonaqueous Oxidative C-N Cleavage of N, N-Dibenzylanilines

A visible-light-driven photoredox-catalyzed nonaqueous oxidative C-N cleavage of N,N-dibenzylanilines to 2° amides is reported. Further, we have applied this protocol on 2-(dibenzylamino)benzamide to afford quinazolinones with (NH4)2S2O8 as an additive. Mechanistic studies imply that the reaction might undergo in situ generation of α-amino radical to imine by C-N bond cleavage followed by the addition of superoxide ion to form amides.

Palladium-Catalyzed Desulfurative Hiyama Coupling of Thioureas to Achieve Amides via Selective C-N Bond Cleavage

Palladium-catalyzed Hiyama coupling of active thioureas via selective C-N bond cleavage is reported. Notably, the new approach employed active thioureas as coupling partners in the presence of arylsilanes to give amides in good yield. Further, this strategy, which utilized CuF 2as a key oxidant and activator, afforded various amide products under mild conditions and an easy to handle procedure without extra base.

Preparation method of amide

The invention relates to a preparation method of an amide, wherein, under the action of oxygen, the isothiocyanate and the aldehyde can react to form an amide, and the reaction temperature can be effectively increased only when not less than 110 °C. This process is also suitable for the reaction of isocyanates with aldehydes to produce amides. The preparation method is cheap in raw material, wide in substrate application range and free of metal catalysts in the reaction process. The initiator or other activator is green and economical, and can effectively reduce the cost.

Visible-light-induced direct construction of amide bond from carboxylic acids with amines in aqueous solution

A novel visible-light-promoted N-acylation for the synthesis of amides from easily available carboxylic acids with amines in the presence of I2 within 2.5 h in aqueous solution has been developed. Using sunlight as the visible light source greatly reduces the cost of experiments and produces almost no toxic effects. Hence, this study provides an alternative catalytic system for the construction of a wide range of amides with readily available materials. Moreover, the strategy was successfully applied in the preparation of N-(3-(2,6-dimethoxyphenoxy)-7-nitroquinoxalin-2-yl)benzohydrazide, which displayed a signification anti-proliferation effect on A549, MCF-7 and HCT116 cell lines.

Carboxylic Acid Deoxyfluorination and One-Pot Amide Bond Formation Using Pentafluoropyridine (PFP)

This work describes the application of pentafluoropyridine (PFP), a cheap commercially available reagent, in the deoxyfluorination of carboxylic acids to acyl fluorides. The acyl fluorides can be formed from a range of acids under mild conditions. We also demonstrate that PFP can be utilized in a one-pot amide bond formation via in situ generation of acyl fluorides. This one-pot deoxyfluorination amide bond-forming reaction gives ready access to amides in yields of ≤94%.

Visible-Light Carbon Nitride-Catalyzed Aerobic Cyclization of Thiobenzanilides under Ambient Air Conditions

A metal-free heterogeneous photocatalysis has been developed for the synthesis of benzothiazoles via intramolecular C-H functionalization/C-S bond formation of thiobenzanilides by inexpensive graphitic carbon nitride (g-C3N4) under visible-light irradiation. This reaction provides access to a broad range of 2-substituted benzothiazoles in high yields under an air atmosphere at room temperature without addition of a strong base or organic oxidizing reagents. In addition, the catalyst was found to be stable and reusable after five reaction cycles.