221642-63-3Relevant academic research and scientific papers
Synthesis of 1-substituted 3-(chloromethyl)-6-aminoindoline (6-amino- seco-CI) DNA minor groove alkylating agents and structure-activity relationships for their cytotoxicity
Milbank, Jared B. J.,Tercel, Moana,Atwell, Graham J.,Wilson, William R.,Hogg, Alison,Denny, William A.
, p. 649 - 658 (2007/10/03)
A series of racemic 6-amino-seco-cyclopropylindole (seco-CI)-compounds was prepared by coupling 1-(tert-butyloxycarbonyl)-3-(chloromethyl)-6- nitroindoline with appropriate acids, followed by nitro group reduction, and evaluated for cytotoxicity in AA8, U
