221684-52-2Relevant articles and documents
ANAPLASTIC LYMPHOMA KINASE MODULATORS AND METHODS OF USE
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Page/Page column 157, (2008/06/13)
The present invention comprises compounds and pharmaceutical compositions comprising the compounds that are inhibitors of ALK. The invention also comprises methods of using the compounds and compositions to treat diseases mediated by ALK, including diseases such as cancer, immunological disorders, cardiovascular diseases, and other degenerative disorders.
Dimerization of o-hydroxycyclohexadienones related to calicheamicinone: S(N)2 displacement of the 12α-hydroxyl group
Churcher, Ian,Hallett, David,Magnus, Philip
, p. 1597 - 1606 (2007/10/03)
Deprotection of the readily available bicyclo[7,3,1]enediyne alcohol 14 resulted in dimerization to give 18. Replacement of the 12α-hydroxyl group with a p-methoxyanilino group proceeded with overall retention to give 23 which also produced a dimer on attempted deprotection.