221684-52-2

Upstream product

• 303-38-8 2,3-Dihydroxybenzoic acid 
• 2411-83-8 methyl-2,3-dihydroxybenzoate 
• 98-88-4 benzoyl chloride 

Downstream Products

• 221684-53-3 methyl 3-benzoyloxy-2-methoxybenzoate 
• 838857-95-7 2-chloro-4-(6-fluoro-1-methyl-8,9-bis{[2-(methyloxy)ethyl]oxy}-3H-pyrazolo[3,4-c]isoquinolin-5-yl)phenol hydrochloride 
• 838858-06-3 4-(5-fluoro-2,3-bis{[2-(methyloxy)ethyl]oxy}phenyl)-3-methyl-1H-pyrazol-5-amine 
• 838857-97-9 methyl 2-{[2-(methyloxy)ethyl]oxy}-5-nitro-3-[(phenylcarbonyl)oxy]benzoate 
• 838857-79-7 methyl 2-[(2-bromoethyl)oxy]-5-nitro-3-[(phenylcarbonyl)oxy]benzoate 
• 838858-05-2 2-(5-fluoro-2,3-bis{[2-(methyloxy)ethyl]oxy}phenyl)-3-oxobutanenitrile 
• 838857-99-1 methyl 2,3-bis{[2-(methyloxy)ethyl]oxy}-5-nitrobenzoate 
• 838858-00-7 methyl 5-amino-2,3-bis{[2-(methyloxy)ethyl]oxy}benzoate 
• 838858-04-1 (5-fluoro-2,3-bis{[2-(methyloxy)ethyl]oxy}phenyl)acetonitrile 
• 838858-03-0 1-(chloromethyl)-5-fluoro-2,3-bis{[2-(methyloxy)ethyl]oxy}benzene 
• 838858-01-8 methyl 5-fluoro-2,3-bis{[2-(methyloxy)ethyl]oxy}benzoate 
• 838858-02-9 (5-fluoro-2,3-bis{[2-(methyloxy)ethyl]oxy}phenyl)methanol 
• 838857-98-0 methyl 3-hydroxy-2-{[2-(methyloxy)ethyl]oxy}-5-nitrobenzoate 
• 838857-78-6 methyl 2-[(2-bromoethyl)oxy]-3-[(phenylcarbonyl)oxy]benzoate 

Relevant academic research and scientific papers

ANAPLASTIC LYMPHOMA KINASE MODULATORS AND METHODS OF USE

The present invention comprises compounds and pharmaceutical compositions comprising the compounds that are inhibitors of ALK. The invention also comprises methods of using the compounds and compositions to treat diseases mediated by ALK, including diseases such as cancer, immunological disorders, cardiovascular diseases, and other degenerative disorders.

Dimerization of o-hydroxycyclohexadienones related to calicheamicinone: S(N)2 displacement of the 12α-hydroxyl group

Deprotection of the readily available bicyclo[7,3,1]enediyne alcohol 14 resulted in dimerization to give 18. Replacement of the 12α-hydroxyl group with a p-methoxyanilino group proceeded with overall retention to give 23 which also produced a dimer on attempted deprotection.