221685-11-6

Basic information

• Product Name: (R)-2-Acetylamino-4-methyl-pentanoic acid ((S)-3-benzyl-1-benzyloxy-2,5-dioxo-pyrrolidin-3-yl)-amide
• CAS NO: 221685-11-6
• Molecular Weight: 465.549
• Mol File: 221685-11-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-2-Acetylamino-4-methyl-pentanoic acid ((S)-3-benzyl-1-benzyloxy-2,5-dioxo-pyrrolidin-3-yl)-amide(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-Acetylamino-4-methyl-pentanoic acid ((S)-3-benzyl-1-benzyloxy-2,5-dioxo-pyrrolidin-3-yl)-amide(221685-11-6)
• EPA Substance Registry System: (R)-2-Acetylamino-4-methyl-pentanoic acid ((S)-3-benzyl-1-benzyloxy-2,5-dioxo-pyrrolidin-3-yl)-amide(221685-11-6)

Safety Data

• Hazardous Substances Data: 221685-11-6(Hazardous Substances Data)

Upstream product

• 19764-30-8 N-acetyl-D-leucine 
• 221685-07-0 (S)-3-Amino-3-benzyl-1-benzyloxy-pyrrolidine-2,5-dione 
• 673-06-3 D-(R)-phenylalanine 
• 131288-30-7 (2R,4R)-3-Benzyloxycarbonyl-2-phenyl-4-phenylmethyl-5-oxooxazolidine 
• 221685-05-8 (2R,4S)-4-Benzyl-4-(benzyloxycarbamoyl-methyl)-5-oxo-2-phenyl-oxazolidine-3-carboxylic acid benzyl ester 
• 221685-06-9 ((S)-3-Benzyl-1-benzyloxy-2,5-dioxo-pyrrolidin-3-yl)-carbamic acid benzyl ester 

Downstream Products

• 221685-12-7 (R)-2-Acetylamino-4-methyl-pentanoic acid ((S)-3-benzyl-1-hydroxy-2,5-dioxo-pyrrolidin-3-yl)-amide 

Relevant articles and documents

Leucine-phenylalanine dipeptide-based N-mesyloxysuccinimides: Synthesis of all four stereoisomers and their assay against serine proteases

The four stereoisomers of 3-(N-acetylleucylamino)-3-benzyl-1- [(methylsulfonyl)oxy]succinimide have been prepared and shown to inhibit α- chymotrypsin and human neutrophil elastase. The structural and stereochemical features that affect the potency and selectivity of inhibition are discussed.