22176-30-3Relevant academic research and scientific papers
Cu(I)-phosphine complex: An efficient catalyst for synthesis of 3-indole derivatives through one-pot MCR under mild conditions
Prasad, Avvari N.,Braga, Felipe C.,Lopes, Rosangela da S.,Casagrande, Gleison A.,de Lima, Dênis P.,Beatriz, Adilson
, p. 104 - 114 (2017/12/26)
An efficient copper (I) halotriphenylphosphine catalyzed one-pot multicomponent reaction (MCR) of 3-substituted indole derivatives has been developed using a variety of aldehydes (aromatic, aliphatic, and heteroaromatic), indole, and active methylene subs
Synthesis, structure and cytotoxicity evaluation of complexes of N1-substituted-isatin-3-thiosemicarbazone with copper(I) halides
Khan, Ashiq,Jasinski, Jerry P.,Smoleaski, Victoria A.,Paul, Kamaldeep,Singh, Gurpinder,Sharma, Rekha
supporting information, p. 119 - 126 (2016/06/01)
Synthesis of Isatin-N1-methyl-thiosemicarbazone (H2itsc-N1-Me, H2L1) and isatin-N1-ethyl-thiosemicarbazone (H2itsc-N1-Et, H2L2) has been carried out and the effect of substituents (at N1 atom of isatin-3-thiosemicarbazones) on nuclearity of copper(I) halide complexes has been investigated. Reactions of copper(I) halides (X = I, Br, Cl) with H2L1 and H2L2 using Ph3P as co-ligand in 1:1:1 (M:L:PPh3) molar ratio in acetonitrile yielded complexes of stoichiometry [CuX(H2L1)(Ph3P)] (X = I, C1; Br, C2; Cl, C3) and [CuX(H2L2)(Ph3P)] (X = I, C4; Br, C5; Cl, C6) respectively. All these complexes have been characterized using analytical and spectroscopic data (IR, 1H NMR and ESI mass). The single crystal structure has been solved for H2L1 and C2. The complex C2 has distorted tetrahedral geometry around copper(I) and isatin-N1-methyl-thiosemicarbazone coordinated to metal center as neutral, bidentate, N3, S-chelating ligand. Elemental analysis suggested the presence of one acetonitrile molecule in complexes C3 and C6 and half CH3CN in complexes C2 and C4 as solvent of crystallization. MTT assay, supported by docking studies have revealed the cytotoxic nature of the compounds C1-C6.
Novel phosphinite and phosphonite copper(I) complexes: Efficient catalysts for click azide-alkyne cycloaddition reactions
Lal, Steven,McNally, Jayne,White, Andrew J. P.,Diez-Gonzalez, Silvia
, p. 6225 - 6232 (2012/01/12)
The preparation of novel phosphinite- and phosphonite-bearing copper(I) complexes of the general formula [CuX(L)] is reported. These compounds, which remain scarce in the literature, could be prepared using readily available starting materials and were spectroscopically and structurally characterized. These complexes, together with their known phosphine and phosphite analogues, were then applied to the 1,3-dipolar cycloaddition of azides and alkynes, to find that the new complexes displayed the best activities. Full optimization of the reaction conditions resulted in a noteworthy Click catalytic system, active under very mild reaction conditions in the absence of any additive and using low metal loadings.
Reactivity of the carbyne complexes [W2(μ-COR)(η5-C5H5)2 (CO)2(μ-Ph2PCH2PPh2)]+ (R = H, Me) toward diazomethane
Alvarez, M. Angeles,García, M. Esther,Riera, Víctor,Ruiz, Miguel A.,Robert, Francis
, p. 1177 - 1183 (2008/10/08)
Reaction of [W2(μ-COH)Cp2(CO)2(μ-dppm)]BF2 (Cp = η5-C5H5; dppm = Ph2PCH2PPh2) with CH2N2 in the presence of CuCl at -75 °C leads to the methoxycarbyne cluster [CuW2Cl(μ3-COMe)Cp2(CO)2(μ-dpp m)]BF4. Copper(I) chloride can be cleanly removed from the latter upon addition of PPh3, thus giving the methoxycarbyne complex [W2(μ-COMe)Cp2(CO)2(μ-dppm)]-BF4 . In the absence of CuCl, either the hydroxy or the methoxycarbyne ditungsten cations react with CH2N2 to give a mixture of the μ-methylene, μ-alkenyl compound [W2(μ-CH2){μ-η1:η2-C(O Me)=CH2}Cp2(CO)2(μ-dppm)]BF4, which has been characterized through an X-ray study, and the μ-alkyne, μ-alkenyl species [W2{μ-η1:η2-C(OMe)CH}{μ-η 1:η2-C(OMe)CH2}Cp2-(CO)(μ-dpp m)]BF4, the latter being the result of the addition of four molecules of CH2N2 to the starting hydroxycarbyne compound. The influence of experimental conditions on the above reactions has been analyzed through separate experiments. For example, the use of tetrahydrofuran as solvent almost suppresses the formation of the alkyne product, whereas the use of a noncoordinating anion such us [B{3,5-C6H3(CF3)2}4] - instead of BF4- as counterion precludes the reaction to occur beyond the methoxycarbyne compound. The solution structures of the new compounds are analyzed in the light of the IR and NMR spectra, and plausible reaction pathways are proposed in order to explain the formation of the reaction products.
Synthesis of triangular mixed-metal clusters by the addition of copper electrophiles to an electron-rich rhodium-rhodium bond. X-ray crystal structures of [Rh2(η-C5H5) 2(μ-CO)(μ-Ph2PCH2PPh 2)(μ-CuI)] and [Rh2(η-C5H5) ...
Bruno, Giuseppe,Lo Schiavo, Sandra,Rotondo, Enrico,Piraino, Pasquale,Faraone, Felice
, p. 2502 - 2507 (2008/10/08)
Full title: Synthesis of triangular mixed-metal clusters by the addition of copper electrophiles to an electron-rich rhodium-rhodium bond. X-ray crystal structures of [Rh2(η-C5H5) 2(μ-CO)(μ-Ph2PCH2PPh 2)(μ-CuI)] and [Rh2(η-C5H5) 2(μ-CO)(μ-Ph2PCH2PPh 2)(μ-AgO2CCH3)]. The new Rh2Cu mixed-metal clusters [Rh2(η-C5H5) 2(μ-CO)(μ-dppm)(μ-CuX)] (X = Cl, 2; X = I, 3; dppm = bis(diphenylphosphino)methane) have been prepared by reacting [Rh2(η-C5H5) 2(μ-CO)(μ-dppm)] (1) with CuX and have been spectroscopically characterized. The structure of 3 has also been established by X-ray crystallography. The compound crystallizes in the orthorhombic space group Pnma with a = 14.002 (2) A?, b = 18.306 (2) A?, c = 13.025 (1) A?, V = 3338.5 A?3, and Z = 4. The structure has been refined to R = 0.034 and Rw = 0.039 for the 1064 reflections with I ≥ 3σ(I). Complex 3 reacts with AgO2CCF3 to yield [Rh2(η-C5H5) 2(μ-CO)(μ-dppm)(μ-AgO2CCF3)] (4) which has been structurally characterized. Crystals of 4 are also orthorhombic of space group Pnma with a = 15.133 (2) A?, b = 18.176 (3) A?, c = 12.656 (1) A?, V = 3481.0 A?3, and Z = 4. R = 0.034 and Rw = 0.034 for the 1993 reflections with I ≥ 3σ(I). In both complexes structurally characterized the three metal atoms define a triangular cluster [in 3 Rh(1)-Rh(1′) = 2.746 (1), Rh(1)-Cu = 2.588 (2) A?; in 4 Rh(1)-Rh(1′) = 2.776 (1), Rh(1)-Ag = 2.719 (1) A?] with the Rh-Rh bond bridged by the dppm and the CO ligands. The rhodium atoms are each symmetrically capped by one η-cyclopentadienyl ligand, and the interplanar angle between the cyclopentadienyl rings can be related to the bulk of the group 11 metal. In 3 the iodine atom is bonded to copper while in 4 the trifluoroacetate group is chelated to the silver atom. The structural features of 3 and 4 have been compared with those of the other compounds of this class already reported. The results show that the formation of stable Rh2Ag and Rh2Cu triangular clusters by addition of electrophiles containing the group 11 metals to 1 requires the use of silver or copper salts of coordinating anions.
Preparation of binuclear copper-cobalt compounds. Crystal structure of (tmed)CuCo(CO)4
Doyle,Eriksen,Van Engen
, p. 877 - 881 (2008/10/08)
The reaction of L2CuCl with Co(CO)4- or Co(CO)3PR3- leads to the formation of binuclear Cu-Co complexes. Solution infrared data indicates that these complexes contain a single Cu-Co bond with no CO-Cu interaction. The solid-state spectra were similar except for that of (tmed)CuCo(CO)4 which exhibits a low-frequency band at 1820 cm-1. A single-crystal structural analysis of this material was undertaken. The molecule [(CH3)2NCH2CH2N(CH3) 2]CuCo(CO)4 crystallizes in the orthorhombic space group Pna21 with a = 16.681 (3) ?, b = 8.797 (1) ?, and c = 9.994 (1) ?. Full-matrix least-squares refinement with anisotropic temperature factors for the non-hydrogen atoms and fixed, isotropic thermal parameters for the hydrogens have converged to R = 0.051 and Rw = 0.053 for the 862 observed reflections. The Cu and Co are bonded at a distance of 2.38 ?. One of the carbonyl groups asymmetrically bridges the Cu-Co bond; the three remaining carbonyls are terminally bonded to the Co atom. The tmed molecule functions as a bidentate ligand on the Cu, which exhibits nearly planar coordination.
