22176-37-0Relevant academic research and scientific papers
Steric demands in the formation of heteroleptic Cu(I) complexes with α-diimines and triphenylphosphine
Tseriotou, Eleni,Tzimopoulos, Dimitris,Hatzidimitriou, Antonis,Akrivos, Pericles
, p. 152 - 157 (2018/07/29)
The synthesis and the study of the molecular structure of a series of heteroleptic copper(I) compounds with triphenylphosphine and α-diimines presenting a varying degree of bulk at their chelating cite is reported. The most sterically crowded diimine acts as a monodentate ligand towards copper(I) promoting bridging of the halogen atom present in the metal coordination sphere and formation of a dimer. Evidence for this behavior is obtained from the electronic spectra and semiempirical quantum chemical calculations with MOPAC. Steric demands in all the studied compounds preclude coordination of silver(I) under similar reaction conditions.
Synthesis, structure and cytotoxicity evaluation of complexes of N1-substituted-isatin-3-thiosemicarbazone with copper(I) halides
Khan, Ashiq,Jasinski, Jerry P.,Smoleaski, Victoria A.,Paul, Kamaldeep,Singh, Gurpinder,Sharma, Rekha
supporting information, p. 119 - 126 (2016/06/01)
Synthesis of Isatin-N1-methyl-thiosemicarbazone (H2itsc-N1-Me, H2L1) and isatin-N1-ethyl-thiosemicarbazone (H2itsc-N1-Et, H2L2) has been carried out and the effect of substituents (at N1 atom of isatin-3-thiosemicarbazones) on nuclearity of copper(I) halide complexes has been investigated. Reactions of copper(I) halides (X = I, Br, Cl) with H2L1 and H2L2 using Ph3P as co-ligand in 1:1:1 (M:L:PPh3) molar ratio in acetonitrile yielded complexes of stoichiometry [CuX(H2L1)(Ph3P)] (X = I, C1; Br, C2; Cl, C3) and [CuX(H2L2)(Ph3P)] (X = I, C4; Br, C5; Cl, C6) respectively. All these complexes have been characterized using analytical and spectroscopic data (IR, 1H NMR and ESI mass). The single crystal structure has been solved for H2L1 and C2. The complex C2 has distorted tetrahedral geometry around copper(I) and isatin-N1-methyl-thiosemicarbazone coordinated to metal center as neutral, bidentate, N3, S-chelating ligand. Elemental analysis suggested the presence of one acetonitrile molecule in complexes C3 and C6 and half CH3CN in complexes C2 and C4 as solvent of crystallization. MTT assay, supported by docking studies have revealed the cytotoxic nature of the compounds C1-C6.
Novel phosphinite and phosphonite copper(I) complexes: Efficient catalysts for click azide-alkyne cycloaddition reactions
Lal, Steven,McNally, Jayne,White, Andrew J. P.,Diez-Gonzalez, Silvia
, p. 6225 - 6232 (2012/01/12)
The preparation of novel phosphinite- and phosphonite-bearing copper(I) complexes of the general formula [CuX(L)] is reported. These compounds, which remain scarce in the literature, could be prepared using readily available starting materials and were spectroscopically and structurally characterized. These complexes, together with their known phosphine and phosphite analogues, were then applied to the 1,3-dipolar cycloaddition of azides and alkynes, to find that the new complexes displayed the best activities. Full optimization of the reaction conditions resulted in a noteworthy Click catalytic system, active under very mild reaction conditions in the absence of any additive and using low metal loadings.
