22179-73-3

Basic information

• Product Name: 3,4-DICHLORO-THIOBENZAMIDE
• Synonyms: OTAVA-BB BB7020331336;3,4-DICHLORO-THIOBENZAMIDE;3,4-DICHLOROTHIOBENZAMIDE 98%;3,4-Dichlorobenzenecarbothioamide
• CAS NO: 22179-73-3
• Molecular Formula: C₇H₅Cl₂NS
• Molecular Weight: 206.09
• Mol File: 22179-73-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 138-142℃
• Boiling Point: 318.4 °C at 760 mmHg
• Flash Point: 146.4 °C
• Appearance: /
• Density: 1.473 g/cm³
• Vapor Pressure: 0.000361mmHg at 25°C
• Refractive Index: 1.669
• Sensitive: Air Sensitive
• CAS DataBase Reference: 3,4-DICHLORO-THIOBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-DICHLORO-THIOBENZAMIDE(22179-73-3)
• EPA Substance Registry System: 3,4-DICHLORO-THIOBENZAMIDE(22179-73-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26
• HazardClass: IRRITANT
• Hazardous Substances Data: 22179-73-3(Hazardous Substances Data)

Usage

General Description

3,4-Dichloro-thiobenzamide is a chemical compound with the molecular formula C7H5Cl2NS. As the name implies, it is derived from thiobenzamide, a type of sulfonamide, but has been substituted with two chlorine atoms at the 3 and 4 positions. This halogenated compound is used in the synthesis of a variety of chemical products, often serving as an intermediate in these processes. The detailed properties such as solubility, melting point, boiling point, and specific optical rotation of 3,4-Dichloro-thiobenzamide rely on factors such as purity and ambient temperature. However, like many chemicals, it needs to be handled with care to avoid risks associated with exposure or ingestion.

InChI:InChI=1/C7H5Cl2NS/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3H,(H2,10,11)

Upstream product

• 6574-99-8 3,4-dichloro-benzonitrile 
• 2670-38-4 3,4-dichlorobenzamide 

Downstream Products

• 1589081-23-1 4-amino-6-(benzo[d][1,3]dioxol-5-yl)-2-((2-(3,4-dichlorophenyl)thiazol-4-yl)methylthio)pyrimidine-5-carbonitrile 
• 1334212-48-4 3,5-bis(3,4-dichlorophenyl)-1,2,4-thiadiazole 
• 1313711-76-0 methyl 4-(dibromomethyl)-2-(3,4-dichlorophenyl)thiazole-5-carboxylate 
• 1313711-63-5 methyl 2-(3,4-dichlorophenyl)-4-methylthiazole-5-carboxylate 
• 89873-43-8 S-<2-(3,4-dichlorophenyl)thiazol-4-yl>methylisothiuronium hydrochloride 
• 78743-09-6 2-<2-(3,4-dichlorophenyl)thiazol-4-yl>acetamide 
• 78743-16-5 3-[2-(3,4-Dichloro-phenyl)-thiazol-4-yl]-4-hydroxy-pyrrole-2,5-dione 
• 89873-42-7 4-(chloromethyl)-2-(3,4-dichlorophenyl)thiazole 
• 78743-02-9 2-<(3,4-dichlorophenyl)thiazol-4-yl>acetate 

Relevant articles and documents

Optimization, Structure-Activity Relationship, and Mode of Action of Nortopsentin Analogues Containing Thiazole and Oxazole Moieties

Plant diseases seriously endanger plant health, and it is very difficult to control them. A series of nortopsentin analogues were designed, synthesized, and evaluated for their antiviral activities and fungicidal activities. Most of these compounds displayed higher antiviral activities than ribavirin. Compounds 1d, 1e, and 12a, with excellent antiviral activities, emerged as novel antiviral lead compounds, among which 1e was selected for further antiviral mechanism research. The mechanism research results indicated that these compounds may play an antiviral role by aggregating viral particles to prevent their movement in plants. Further fungicidal activity tests revealed that nortopsentin analogues displayed broad-spectrum fungicidal activities. Compounds 2p and 2f displayed higher antifungal activities against Alternaria solani than the commercial fungicides carbendazim and chlorothalonil. Current research has laid a foundation for the application of nortopsentin analogues in plant protection.

Optimizing thiadiazole analogues of resveratrol versus three chemopreventive targets

Chemoprevention is an approach to decrease cancer morbidity and mortality through inhibition of carcinogenesis and prevention of disease progression. Although the trans stilbene derivative resveratrol has chemopreventive properties, its action is compromised by weak non-specific effects on many biological targets. Replacement of the stilbene ethylenic bridge of resveratrol with a 1,2,4-thiadiazole heterocycle and modification of the substituents on the two aromatic rings afforded potential chemopreventive agents with enhanced potencies and selectivities when evaluated as inhibitors of aromatase and NF-κB and inducers of quinone reductase 1 (QR1).