22179-73-3

Usage

Uses

Used in Chemical Synthesis:
3,4-Dichloro-thiobenzamide is used as a chemical intermediate for the synthesis of various chemical products. Its unique structure with two chlorine atoms at the 3 and 4 positions allows for further reactions and modifications, making it a valuable component in the production of a range of compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3,4-Dichloro-thiobenzamide is used as a building block for the development of new drugs. Its chemical properties and reactivity enable the creation of novel drug candidates with potential therapeutic applications.
Used in Agrochemical Industry:
3,4-Dichloro-thiobenzamide is also used in the agrochemical industry as a precursor for the synthesis of pesticides and other agricultural chemicals. Its versatility in chemical reactions allows for the development of effective products to protect crops and enhance agricultural productivity.
Used in Dye and Pigment Industry:
In the dye and pigment industry, 3,4-Dichloro-thiobenzamide is used as a starting material for the production of various dyes and pigments. Its chemical structure contributes to the color and properties of the final products, making it an essential component in the manufacturing process.

InChI:InChI=1/C7H5Cl2NS/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3H,(H2,10,11)

Upstream product

• 6574-99-8 3,4-dichloro-benzonitrile 
• 2670-38-4 3,4-dichlorobenzamide 

Downstream Products

• 78743-02-9 2-<(3,4-dichlorophenyl)thiazol-4-yl>acetate 
• 1313711-63-5 methyl 2-(3,4-dichlorophenyl)-4-methylthiazole-5-carboxylate 
• 1313711-76-0 methyl 4-(dibromomethyl)-2-(3,4-dichlorophenyl)thiazole-5-carboxylate 
• 1589081-23-1 4-amino-6-(benzo[d][1,3]dioxol-5-yl)-2-((2-(3,4-dichlorophenyl)thiazol-4-yl)methylthio)pyrimidine-5-carbonitrile 
• 1334212-48-4 3,5-bis(3,4-dichlorophenyl)-1,2,4-thiadiazole 
• 89873-43-8 S-<2-(3,4-dichlorophenyl)thiazol-4-yl>methylisothiuronium hydrochloride 
• 78743-09-6 2-<2-(3,4-dichlorophenyl)thiazol-4-yl>acetamide 
• 78743-16-5 3-[2-(3,4-Dichloro-phenyl)-thiazol-4-yl]-4-hydroxy-pyrrole-2,5-dione 
• 89873-42-7 4-(chloromethyl)-2-(3,4-dichlorophenyl)thiazole 

Relevant academic research and scientific papers

Optimization, Structure-Activity Relationship, and Mode of Action of Nortopsentin Analogues Containing Thiazole and Oxazole Moieties

Plant diseases seriously endanger plant health, and it is very difficult to control them. A series of nortopsentin analogues were designed, synthesized, and evaluated for their antiviral activities and fungicidal activities. Most of these compounds displayed higher antiviral activities than ribavirin. Compounds 1d, 1e, and 12a, with excellent antiviral activities, emerged as novel antiviral lead compounds, among which 1e was selected for further antiviral mechanism research. The mechanism research results indicated that these compounds may play an antiviral role by aggregating viral particles to prevent their movement in plants. Further fungicidal activity tests revealed that nortopsentin analogues displayed broad-spectrum fungicidal activities. Compounds 2p and 2f displayed higher antifungal activities against Alternaria solani than the commercial fungicides carbendazim and chlorothalonil. Current research has laid a foundation for the application of nortopsentin analogues in plant protection.

Agonists for the adenosine A1 receptor with tunable residence time. a case for nonribose 4-amino-6-aryl-5-cyano-2-thiopyrimidines

We report the synthesis and evaluation of previously unreported 4-amino-6-aryl-5-cyano-2-thiopyrimidines as selective human adenosine A 1 receptor (hA1AR) agonists with tunable binding kinetics, this without affecting their nanomolar affinity for the target receptor. They show a very diverse range of kinetic profiles (from 1 min (compound 52) to 1 h (compound 43)), and their structure-affinity relationships (SAR) and structure-kinetics relationships (SKR) were established. When put in perspective with the increasing importance of binding kinetics in drug discovery, these results bring new evidence of the consequences of affinity-only driven selection of drug candidates, that is, the potential elimination of slightly less active compounds that may display preferable binding kinetics.

Optimizing thiadiazole analogues of resveratrol versus three chemopreventive targets

Chemoprevention is an approach to decrease cancer morbidity and mortality through inhibition of carcinogenesis and prevention of disease progression. Although the trans stilbene derivative resveratrol has chemopreventive properties, its action is compromised by weak non-specific effects on many biological targets. Replacement of the stilbene ethylenic bridge of resveratrol with a 1,2,4-thiadiazole heterocycle and modification of the substituents on the two aromatic rings afforded potential chemopreventive agents with enhanced potencies and selectivities when evaluated as inhibitors of aromatase and NF-κB and inducers of quinone reductase 1 (QR1).