2670-38-4

Usage

Uses

Used in Pharmaceutical Industry:
3,4-Dichlorobenzamide is used as an intermediate in the synthesis of various pharmaceuticals for its potential role in the development of new drugs and medicinal compounds.
Used in Agrochemical Industry:
In the agrochemical sector, 3,4-Dichlorobenzamide is utilized as an intermediate in the production of agrochemicals, contributing to the development of pesticides and other agricultural chemicals.
Used in Dye and Pigment Production:
3,4-Dichlorobenzamide is used as a building block in the creation of dyes and pigments, playing a crucial role in the coloration of various products in industries such as textiles, plastics, and printing inks.
Used in Specialty Chemicals Industry:
3,4-DICHLOROBENZAMIDE is also employed in the production of specialty chemicals, where its unique properties can be leveraged for specific applications in various industrial processes.

InChI:InChI=1/C7H5Cl2NO/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3H,(H2,10,11)

Upstream product

• 3024-72-4 3,4-dichlorobenzoyl chloride 
• 6574-99-8 3,4-dichloro-benzonitrile 
• 2642-63-9 3',4'-dichloroacetophenone 
• 18282-59-2 4-bromo-1,2-dichlorobenzene 
• 3019-71-4 Trichloroacetyl isocyanate 
• 6287-38-3 3,4-dichlorobenzaldehyde 
• 1805-32-9 3,4-dichlorobenzyl alcohol 
• 5331-92-0 3,4-dichlorobenzaldehyde oxime 
• 102-49-8 3,4-dichlorobenzyl amine 
• 79-37-8 oxalyl dichloride 
• 51-44-5 3,4-dichlorbenzoic acid 
• 201230-82-2 carbon monoxide 
• 20555-91-3 3,4-dichloroiodobenzene 

Downstream Products

• 100726-73-6 3,4-dichloro-benzoic acid-[bis-(2-cyano-ethyl)-amide] 
• 10278-20-3 3,4-dichlorobenzoyl isocyanate 
• 67048-88-8 5-(3,4-dichloro-phenyl)-[1,3,4]oxathiazol-2-one 
• 6574-99-8 3,4-dichloro-benzonitrile 
• 64248-62-0 3,4-Difluorobenzonitrile 
• 67113-97-7 3-(3,4-dichloro-phenyl)-isothiazole-4-carboxylic acid 
• 67049-20-1 3-(3,4-dichloro-phenyl)-isothiazole-4-carboxylic acid ethyl ester 
• 67048-66-2 3-(3,4-dichloro-phenyl)-isothiazole-4,5-dicarboxylic acid 
• 59291-75-7 3-(3,4-dichloro-phenyl)-isothiazole-4,5-dicarboxylic acid dimethyl ester 
• 57870-51-6 ethyl 3,4-dichlorobenzimidate 
• 945257-69-2 3,4-dichloro-N-{4-[(5,5-dimethyl-2,4-dioxo-3-{4-[(trifluoro-methyl)thio]phenyl}imidazolidin-1-yl)methyl]pyridin-2-yl}benzamide 
• 1322085-22-2 N-[6-(tert-butyl-dimethyl-silanyloxymethyl)-pyridin-3-yl]-3,4-dichloro-benzamide 
• 22179-73-3 3,4-dichlorobenzothioamide 
• 349107-09-1 3,4-dichloro-N-(pyridin-2-yl)benzamide 

Relevant academic research and scientific papers

Green and efficient Beckmann rearrangement by Cu(II) contained nano-silica triazine based dendrimer in water

In this research, a Cu(II) contained nano-silica triazine based dendrimer was prepared, characterized, and utilized as a retrievable catalytic system (Cu(II)-TrDen@nSiO2) for green formation of primary amides in water at room temperature. The structure of nanoparticles was fully characterized by using scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDX), Fourier transform infrared spectroscopy (FT-IR), and thermogravimetry analysis (TGA). The results revealed that the nanoparticles have spherical morphology and an average size of around 40 nm. The analysis also illustrated that the copper nanoparticles had been successfully loaded on the nitrogen-rich dendritic structure with a uniform distribution. The inductively coupled plasma analysis showed that about 0.67 mmol/g of Cu was loaded on the Cu(II)-TrDen@nSiO2 support. Mild reaction conditions, excellent yields, environment-friendly synthesis, and easily prepared starting materials are the key features of the present method. The catalyst is easily removed from the reaction media using a simple filtration and can be re-used at least five times without any considerable loss of its catalytic activity.

Efficient nitriding reagent and application thereof

The invention discloses an efficient nitriding reagent and application thereof, wherein the nitriding reagent comprises nitrogen oxide, an active agent, a reducing agent and an organic solvent. By applying the nitriding reagent, nitrogen-containing compounds such as amide, nitrile and the like can be produced, and the method is simple in condition, low in waste discharge amount and simple in reaction equipment.

Supported palladium catalyzed aminocarbonylation of aryl iodides employing bench-stable CO and NH3surrogates

A simple, efficient and phosphine free protocol for carbonylative synthesis of primary aromatic amides under polystyrene supported palladium (Pd?PS) nanoparticle (NP) catalyzed conditions has been demonstrated. Herein, instead of using two toxic and difficult to handle gases simultaneously, we have employed the solid, economical, bench stable oxalic acid as the CO source and ammonium carbamate as the NH3source in a single pot reaction. For the first time, we have applied two non-gaseous surrogates simultaneously under heterogeneous catalyst (Pd?PS) conditions for the synthesis of primary amides using an easy to handle double-vial (DV) system. The developed strategy showed a good functional group tolerance towards a wide range of aryl iodides and afforded primary aromatic amides in good yields. The Pd?PS catalyst was easy to separate and can be recycled up to four consecutive runs with small loss in catalytic activity. We have successfully extended the scope of the methodology to the synthesis of isoindole-1,3-diones from 1,2-dihalobenzene, 2-halobenzoates and 2-halobenzoic acid following double and single carbonylative cyclization approaches.

Cu(II)–metformin immobilized on graphene oxide: an efficient and recyclable catalyst for the Beckmann rearrangement

Abstract: In this study, for the first time, the copper(II) nanoparticles (NPs) have been immobilized on metformin-functionalized graphene oxide and then its catalytic applications have been investigated in synthesis of amides from aldoximes (Beckmann rearrangement). The chemical structure of prepared catalyst has been characterized by various analyses like FT-IR, TGA, TEM, SEM, EDX, and ICP. All analyses confirm the successful and stable immobilization of copper NPs on functionalized graphene oxide. This synthesized heterogeneous nanocatalyst showed excellent catalytic activity with high product yields and short reaction times. Also, the suggested catalyst could be recycled ten times without a drastic decrease in its catalytic activity. Graphic abstract: [Figure not available: see fulltext.].

Nitromethane as a nitrogen donor in Schmidt-type formation of amides and nitriles

The Schmidt reaction has been an efficient and widely used synthetic approach to amides and nitriles since its discovery in 1923. However, its application often entails the use of volatile, potentially explosive, and highly toxic azide reagents. Here, we report a sequence whereby triflic anhydride and formic and acetic acids activate the bulk chemical nitromethane to serve as a nitrogen donor in place of azides in Schmidt-like reactions. This protocol further expands the substrate scope to alkynes and simple alkyl benzenes for the preparation of amides and nitriles.

DNA POLYMERASE IIIC INHIBITORS AND USE THEREOF

The present invention relates to compounds and methods useful for inhibiting the DNA polymerase IIIC enzyme. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of Gram-positive bacterial infections.

Discovery of a New Isoxazole-3-hydroxamate-Based Histone Deacetylase 6 Inhibitor SS-208 with Antitumor Activity in Syngeneic Melanoma Mouse Models

Isoxazole is a five-membered heterocycle that is widely used in drug discovery endeavors. Here, we report the design, synthesis, and structural and biological characterization of SS-208, a novel HDAC6-selective inhibitor containing the isoxazole-3-hydroxamate moiety as a zinc-binding group as well as a hydrophobic linker. A crystal structure of the Danio rerio HDAC6/SS-208 complex reveals a bidentate coordination of the active-site zinc ion that differs from the preferred monodentate coordination observed for HDAC6 complexes with phenylhydroxamate-based inhibitors. While SS-208 has minimal effects on the viability of murine SM1 melanoma cells in vitro, it significantly reduced in vivo tumor growth in a murine SM1 syngeneic melanoma mouse model. These findings suggest that the antitumor activity of SS-208 is mainly mediated by immune-related antitumor activity as evidenced by the increased infiltration of CD8+ and NK+ T cells and the enhanced ratio of M1 and M2 macrophages in the tumor microenvironment.

Metal-Free Thermal Activation of Molecular Oxygen Enabled Direct α-CH2-Oxygenation of Free Amines

Direct oxidation of α-CH2 group of free amines is hard to achieve due to the higher reactivity of amine moiety. Therefore, oxidation of amines involves the use of sophisticated metallic reagents/catalyst in the presence or absence of hazardous oxidants under sensitive reaction conditions. A novel method for direct C-H oxygenation of aliphatic amines through a metal-free activation of molecular oxygen has been developed. Both activated and unactivated free amines were oxygenated efficiently to provide a wide variety of amides (primary, secondary) and lactams under operationally simple conditions without the aid of metallic reagents and toxic oxidants. The method has been applied to the synthesis of highly functionalized amide-containing medicinal drugs, such as O-Me-alibendol and -buclosamide.

Novel design of recyclable copper(II) complex supported on magnetic nanoparticles as active catalyst for Beckmann rearrangement in poly(ethylene glycol)

Copper complex-functionalized magnetic core–shell nanoparticles (Fe3O4@SiO2-Lig-Cu) were prepared and characterized using various techniques. The activity of the new catalyst was tested for the Beckmann rearrangement. The reaction conditions allow for the conversion of a wide variety of aldoximes, including aromatic and heterocyclic ones, to amides in good to excellent yields. High efficiency, mild reaction conditions, easy work-up, use of poly(ethylene glycol) as a green medium and simple purification of products are important advantages of this system. Moreover, the eco-friendly heterogeneous nanocatalyst could be easily recovered from the reaction mixture using an external magnet and reused several times.

A method of from [...] amide

The invention discloses a method for synthesizing amides from oxime. The method is characterized by adding oxime, water and a water-soluble iridium complex catalyst to a reaction vessel, cooling a reactant to the room temperature after the reaction mixture reacts at 80-120 DEG C for several hours, removing water through selective evaporation, and obtaining a target product through column separation. Compared with existing methods for synthesizing amides through oxime rearrangement in water through transition metal catalysis, the method has the advantages that the used catalyst is low in load and does not contain phosphine ligands severely polluting the environment, so that the reaction can be carried out in the air, without nitrogen protection; therefore the reaction meets the green chemical requirements and has an extensive development prospect.