22179-83-5

Upstream product

• 612-24-8 o-nitrobenzonitrile 
• 35447-75-7 N-hydroxy-2-nitrobenzimidoyl chloride 
• 88-74-4 2-nitro-aniline 

Downstream Products

• 86339-16-4 C₁₄H₁₁N₃O₄ 
• 336608-12-9 5-methyl-3-(2-nitrophenyl)-1,2,4-oxadiazole 
• 1041005-70-2 N-isopropyl-3-(2-nitrophenyl)-1,2,4-oxadiazol-5-amine 
• 81467-55-2 1-[3-(2-Nitro-phenyl)-[1,2,4]oxadiazol-5-yl]-propan-2-one 
• 81467-54-1 C₁₁H₁₁N₃O₅ 
• 1443017-25-1 3-(2-nitrophenyl)-5-(p-tolyl)-1,2,4-oxadiazole 
• 1443017-24-0 5-(4-fluorophenyl)-3-(2-nitrophenyl)-1,2,4-oxadiazole 
• 76108-74-2 3-(2-nitrophenyl)-5-phenyl-1,2,4-oxadiazole 
• 4128-37-4 1,3-diisopropylurea 

Relevant academic research and scientific papers

Imidazole hydrochloride promoted synthesis of 3,5-disubstituted-1,2,4-oxadiazoles

Imidazole hydrochloride as an additive promotes the reaction of amidoximes and DMA derivatives to generated 3,5-disubstituted-1,2,4-oxadiazoles in low to excellent yields without the use of coupling reagents, oxidants, strong acids or bases and other additives.

Synthesis and Properties of Energetic 1,2,4-Oxadiazoles

The synthesis and characterization of a series of 3,5-di-aryl-1,2,4-oxadiazoles are reported and the effects of nitro groups in the aromatic rings on the experimental heats of decomposition (ΔHd) and heats of combustion (ΔHc) are evaluated. Heats of formation (ΔHf) and densities (ρ) were calculated and correlations between ΔHd and ΔHf were assessed for these compounds. Experimental determination of ρ (by gas pycnometry) on a selection of the compounds led to the calculation of detonation velocity (VD), detonation pressure (PD) and specific impulse (ISP) parameters by the Explo 5 program. An X-ray analysis of compound (4i) confirmed the structure and showed a crystal density (at 120 K) close to that determined by gas pycnometry.

Synthesis of 3,5-disubstituted-1,2,4-oxadiazoles using tetrabutylammonium fluoride as a mild and efficient catalyst

Tetrabutylammonium fluoride (TBAF) was found to be a mild and efficient catalyst for the synthesis of 3,5-disubstituted-1,2,4-oxadiazoles. Using 0.1 - 1.0 equivalents of TBAF in THF for 1 - 24 h at room temperature, alkanoyl- and aroyloxyamidines were converted in high yield to the corresponding 3,5-disubstituted-1,2,4-oxadiazoles. A variety of R and R′ substituents were investigated.