336608-12-9

Basic information

• Product Name: 5-methyl-3-(2-nitrophenyl)-1,2,4-oxadiazole
• Synonyms: 5-methyl-3-(2-nitrophenyl)-1,2,4-oxadiazole
• CAS NO: 336608-12-9
• Molecular Weight: 205.173
• Mol File: 336608-12-9.mol

Chemical Properties

• CAS DataBase Reference: 5-methyl-3-(2-nitrophenyl)-1,2,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methyl-3-(2-nitrophenyl)-1,2,4-oxadiazole(336608-12-9)
• EPA Substance Registry System: 5-methyl-3-(2-nitrophenyl)-1,2,4-oxadiazole(336608-12-9)

Safety Data

• Hazardous Substances Data: 336608-12-9(Hazardous Substances Data)

Upstream product

• 612-24-8 o-nitrobenzonitrile 
• 22179-83-5 N-hydroxy-2-nitro-benzamidine 
• 108-24-7 acetic anhydride 
• 127-19-5 N,N-dimethyl acetamide 
• 22179-83-5 N'-hydroxy-2-nitrobenzimidamide 

Downstream Products

• 29368-94-3 3-(2-aminophenyl)-5-methyl-1,2,4-oxadiazole 

Relevant articles and documents

Imidazole hydrochloride promoted synthesis of 3,5-disubstituted-1,2,4-oxadiazoles

Imidazole hydrochloride as an additive promotes the reaction of amidoximes and DMA derivatives to generated 3,5-disubstituted-1,2,4-oxadiazoles in low to excellent yields without the use of coupling reagents, oxidants, strong acids or bases and other additives.

Imidazoline derivatives as alpha-1A adrenoceptor ligands

Compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof are disclosed. Such compounds are useful in the treatment of Alpha-1A mediated diseases or conditions such as urinary incontinence.

Synthesis of 3,5-disubstituted-1,2,4-oxadiazoles using tetrabutylammonium fluoride as a mild and efficient catalyst

Tetrabutylammonium fluoride (TBAF) was found to be a mild and efficient catalyst for the synthesis of 3,5-disubstituted-1,2,4-oxadiazoles. Using 0.1 - 1.0 equivalents of TBAF in THF for 1 - 24 h at room temperature, alkanoyl- and aroyloxyamidines were converted in high yield to the corresponding 3,5-disubstituted-1,2,4-oxadiazoles. A variety of R and R′ substituents were investigated.