22184-40-3

Basic information

• Product Name: 7H-1,2,4-Triazolo[3,4-b][1,3,4]thiadiazine, 6-(4-methoxyphenyl)-
• CAS NO: 22184-40-3
• Molecular Formula: C11H10N4OS
• Molecular Weight: 246.293
• Mol File: 22184-40-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 7H-1,2,4-Triazolo[3,4-b][1,3,4]thiadiazine, 6-(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 7H-1,2,4-Triazolo[3,4-b][1,3,4]thiadiazine, 6-(4-methoxyphenyl)-(22184-40-3)
• EPA Substance Registry System: 7H-1,2,4-Triazolo[3,4-b][1,3,4]thiadiazine, 6-(4-methoxyphenyl)-(22184-40-3)

Safety Data

• Hazardous Substances Data: 22184-40-3(Hazardous Substances Data)

Upstream product

• 4343-75-3 4-amino-3-mercapto-1,2,4-triazole 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 4343-75-3 4-amino-2,4-dihydro-[1,2,4]triazole-3-thione 

Downstream Products

• 1083071-84-4 1-acetyl-7-acetylsulfanyl-6-(p-methoxyphenyl)-1H-pyrazolo[5,1-c][1,2,4]triazole 

Relevant articles and documents

Synthesis and anticonvulsant activity evaluation of 6-phenyl-7H [1, 2, 4]triazolo[3, 4-b][1, 3, 4]thiadiazines

Various 6-phenyl-7H-[1, 2, 4]triazolo[3, 4-b][1, 3, 4]thiadiazine derivatives (3a-3n) were designed keeping in view the wide bioactivities of 1, 2, 4-triazoles and their fused heterocyclic derivatives. All target compounds 3a-3n, characterized by IR, 1H-NMR and MS, have been evaluated for their anticonvulsant activity against MES-induced seizures. The pharmacological results showed that most of the compounds displayed some degree of anticonvulsant activity. Among them, 6-(4-chlorophenyl)-7H-[1,2, 4]triazolo[3, 4-b][1,3,4]thiadiazine (3h) was the most promising compound with an ED50 value of 40.9 mg/kg and a PI value of 6.5.

CONDENSED SYSTEMS BASED ON 4-AMINO-3-MERCAPTO-1,2,4-TRIAZOLE

1,2,4-Triazolo-1,3,4-thiadiazines, hydrazones, and β-thio adducts were obtained by reactions of 4-amino-3-mercapto-1,2,4-triazole with ω-bromoacetophenones, aldehydes, and α,β-unsaturated ketones.Conditions that promote the cyclocondensation of the