22184-41-4Relevant academic research and scientific papers
Effective synthesis of 7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazines
Kulikov, Alexander S.,Epishina, Margarita A.,Fershtat, Leonid L.,Makhova, Nina N.
, p. 669 - 672 (2018/08/17)
[Figure not available: see fulltext.] A highly effective method for the preparation of 7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazines was developed on the basis of condensation reaction between aryl(hetaryl) α-bromo ketones and commercially available thiocarbohydrazide, followed by treatment of the obtained 2-hydrazinyl-6H-1,3,4-thiadiazine hydrobromides with ortho esters in the presence of trifluoroacetic acid under mild conditions.
Synthesis and anticonvulsant activity evaluation of 6-phenyl-7H [1, 2, 4]triazolo[3, 4-b][1, 3, 4]thiadiazines
Song, Ming-Xia,Zhang, Chun-Bo,Deng, Xian-Qing,Sun, Zhi-Gang,Quan, Zhe-Shan
experimental part, p. 769 - 773 (2012/04/18)
Various 6-phenyl-7H-[1, 2, 4]triazolo[3, 4-b][1, 3, 4]thiadiazine derivatives (3a-3n) were designed keeping in view the wide bioactivities of 1, 2, 4-triazoles and their fused heterocyclic derivatives. All target compounds 3a-3n, characterized by IR, 1H-NMR and MS, have been evaluated for their anticonvulsant activity against MES-induced seizures. The pharmacological results showed that most of the compounds displayed some degree of anticonvulsant activity. Among them, 6-(4-chlorophenyl)-7H-[1,2, 4]triazolo[3, 4-b][1,3,4]thiadiazine (3h) was the most promising compound with an ED50 value of 40.9 mg/kg and a PI value of 6.5.
CONDENSED SYSTEMS BASED ON 4-AMINO-3-MERCAPTO-1,2,4-TRIAZOLE
Kolos, N. N.,Orlov, V. D.,Slobodina, E. K.,Yur'eva, E. Yu.,Korshunov, S. P.,Tue, Zyong van
, p. 222 - 227 (2007/10/02)
1,2,4-Triazolo-1,3,4-thiadiazines, hydrazones, and β-thio adducts were obtained by reactions of 4-amino-3-mercapto-1,2,4-triazole with ω-bromoacetophenones, aldehydes, and α,β-unsaturated ketones.Conditions that promote the cyclocondensation of the
