221885-33-2Relevant academic research and scientific papers
Chemoenzymatic total synthesis of (+)-conagenin, a low-molecular-weight immunomodulator
Sano, Shigeki,Miwa, Toshio,Hayashi, Kazuhiko,Nozaki, Kazuo,Ozaki, Yohei,Nagao, Yoshimitsu
, p. 4029 - 4031 (2007/10/03)
Total synthesis of (+)-conagenin, a low-molecular-weight immunomodulator, was achieved based on enantioselective enzymatic reactions followed by chemoselective reductions.
Diastereo- and enantioselective formal synthesis of (+)-conagenin via asymmetric [2,3]-Wittig rearrangement
Enders, Dieter,Bartsch, Michael,Runsink, Jan
, p. 243 - 248 (2007/10/03)
The formal synthesis of the immunomodulator (+)-conagenin (1) is accomplished in a twelve-step sequence with good overall yield (19%), diastereoselectivity and enantiomeric excess (ds(syn) = 88%, ee = 91%). Key steps of the synthesis are the asymmetric [2
