221887-91-8Relevant academic research and scientific papers
Catalytic enantioselective alkylation of substituted dioxanone enol ethers: ready access to C(α)-tetrasubstituted hydroxyketones, acids,and esters
Seto, Masaki,Roizen, Jennifer L.,Stoltz, Brian M.
, p. 6873 - 6876 (2008)
(Chemical Equation Presented) Adaptive Alkylation: Palladium-catalyzed asymmetric alkylation enables access to fully substituted enantioenriched oxygenated stereocenters, which can be transformed easily to α-hydroxyketones, esters, and acids, providing a catalytic, enantioselective synthesis for natural products.
Formal synthesis of englerin A utilizing regio- and diastereoselective [4+3] cycloaddition
Hagihara, Shuichi,Hanaya, Kengo,Sugai, Takeshi,Shoji, Mitsuru
, p. 257 - 262 (2018)
Englerin A, a guaiane sesquiterpene isolated from Phyllanthus engleri, showed highly potent and selective growth inhibitory activities against renal cancer cell lines. We synthesized the key tricyclic intermediate from commercially available 2,2-dimethyl-1,3-dioxan-5-one via regio- and diastereoselective [4+3] cycloaddition between the formyl enol silyl ether and the disubstituted furan, in 4.8% total yield over 10 steps.
