221907-27-3Relevant academic research and scientific papers
Synthesis and C-alkylation of C-protected β-enamino acid derivatives from oxa- thia- and imidazolines
Fustero, Santos,Diaz, Ma. Dolores,Asensio, Amparo,Navarro, Antonio,Kong, Jiang She,Aguilar, Enrique
, p. 2695 - 2712 (2007/10/03)
Various heterocycles 3a-h can be readily metallated and condensed with a variety of organic nitriles to afford C-protected β-enamino acid derivatives 1 (or 2). Procedures for alkylation of compounds 1 to obtain 2 as well as a 'one-pot' preparation of 2 from 3 are also described.
A new and mild synthesis of β-amino acids from masked β-enamino acid derivatives
Fustero, Santos,Diaz, M. Dolores,Navarro, Antonio,Salavert, Esther,Aguilar, Enrique
, p. 1005 - 1008 (2007/10/03)
A new method of synthesis of racemic β-amino acids 6 by reduction of masked N-substituted and N-unsubstituted β-enamino acid derivatives 4 via C- protected β-amino acids 5 is described. The process occurs with high yields, total chemoselectivity and moderate diastereoselectivity. Readily available starting materials, inexpensive reagents and mild conditions are used to furnish derivatives 5 and 6.
