221909-90-6

Upstream product

• 201230-82-2 carbon monoxide 
• 696-62-8 para-iodoanisole 
• 103529-16-4 2-[(trimethylsilyl)ethynyl]aniline 
• 100-07-2 4-methoxy-benzoyl chloride 
• 199454-06-3 (2-ethynylphenyl)carbamic acid 1,1-dimethylethyl ester 
• 615-43-0 2-iodophenylamine 
• 52670-38-9 2-ethynylaniline 

Downstream Products

• 929602-13-1 (E)-2-(4-methoxyphenyl)-4-styrylquinoline 
• 1035989-30-0 2-(4-methoxyphenyl)-4-(1-naphthyl)quinoline 
• 1149749-64-3 C₂₅H₂₂N₂O₂ 
• 1099705-55-1 2-(4-methoxyphenyl)-N,N-dimethylquinolin-4-amine 
• 104749-68-0 (1H-indol-2-yl)(4-methoxyphenyl)methanone 
• 1417697-01-8 4-(4-methoxyphenyl)-1H-[1,2,3]triazolo[4,5-c]quinoline 
• 1374756-09-8 4-iodo-2-(4-methoxyphenyl)quinoline 
• 1356490-64-6 methyl 3-{3-[2-(4-methoxyphenyl)quinolin-4-yl]-1H-indol-2-yl}benzoate 
• 1356490-62-4 2-(4-methoxyphenyl)-4-[2-(2-thienyl)-1H-indol-3-yl]quinoline 
• 1356490-59-9 2-(4-methoxyphenyl)-4-(2-phenyl-1H-indol-3-yl)quinoline 

Relevant academic research and scientific papers

TBAF-Catalyzed Tandem Synthesis of Triazolo[4,5-c]quinolines at Ambient Temperature

A mild, efficient and metal-free synthetic method for 1H-[1,2,3]triazolo[4,5-c]quinolines has been developed via intermolecular [3+2] cycloaddition of β-(2-aminoaryl)-α,β-ynones and TMS-N3, followed by intramolecular dehydration annulation sequential reactions. With 5 mmol-% of TBAF as catalyst, the reaction can smoothly proceed in DMF at ambient temperature to afford a wide range of functionalized 1H-[1,2,3]triazolo[4,5-c]quinolines in good to excellent yields.

An Improved Environmentally Friendly Approach to 4-Nitro-, 4-Sulfonyl-, and 4-Aminoquinolines and 4-Quinolones through Conjugate Addition of Nucleophiles to β-(2-Aminophenyl)-α,β-ynones

Sequential addition/annulation reactions of sulfinate and nitrite anions to β-(2-aminophenyl)-α,β-ynones led to valuable 4-sulfonylquinolines and 4-nitroquinolines. The latter proved to be versatile precursors of N-unsubstituted 4-aminoquinolines and 4-quinolones. Reaction of β-(2-aminophenyl)-α,β-ynones with DMF/NaOH resulted in the formation of 4-(dimethylamino)quinolines. The use of an alternative CO-free procedure for the preparation of substrates β-(2-aminophenyl)-α,β-ynones allowed extension of the methodology to the synthesis of 4-substituted 2-alkylquinolines.

The palladium-catalyzed transfer hydrogenation/heterocyclization of β- (2-aminophenyl)-α,β-ynones. An approach to 2-aryl- and 2-vinylquinolines

The palladium-catalyzed transfer hydrogenation/cyclization of readily available β-(o-aminophenyl)-α,β-ynones I affords 2-aryl- and 2- vinylquinolines 3 in good yield.