22192-00-3Relevant academic research and scientific papers
Synthesis of quinolines from N-tosyl-1-azadienes
Stokes, Sean,Mead, Keith T.
, p. 2627 - 2633 (2013/07/26)
A route to aryl-substituted quinolines from N-tosyl 1-azadienes is described. The key steps are a [4 + 2] cycloaddition with benzyne followed by base treatment of the 1,4-dihydroquinoline product. The N-tosyl 1-azadienes were prepared from readily accessible cinnamaldehyde and chalcone substrates by condensation with p-TsNH2. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications to view the free supplemental file.
