222020-96-4

Upstream product

• 32363-92-1 1,1-dibromo-3-methyl-1-butene 
• 3391-87-5 l-menthone 
• 598-23-2 3-methyl-but-1-yne 

Downstream Products

• 222020-99-7 1-Chloro-4-{(R)-1-[(2R,5S)-2-isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-2-methyl-propyl}-benzene 
• 222020-98-6 Carbonic acid (1S,2R,5S)-2-isopropyl-5-methyl-1-((E)-3-methyl-but-1-enyl)-cyclohexyl ester methyl ester 
• 222021-01-4 {(R)-1-[(2R,5S)-2-Isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-2-methyl-propyl}-benzene 

Relevant academic research and scientific papers

Chiral α-substituted carbonyls and alcohols from the S(N)2' displacement of cuprates on chiral carbonates: An alternative to the alkylation of chiral enolates

A highly stereoselective sequence of reactions, based on the anti-selective S(N)2' addition of cuprates to allylic carbonates, transforms alkynes or alkenyl halides into carbonyls having α-chiral centers. The method, which uses menthone as a chiral auxiliary, is a useful alternative to the alkylation of chiral enolates with the added advantage of allowing for the 'alkylation' of sec- and tert-alkyl and aryl groups.

Efficient syntheses of optically active 2-arylalkanoic acids

A highly enantioselective synthesis of 2-axylpropanoic acid was achieved, using a new developed methodology of cuprate addition to chiral carbonates derived from menthone.