222021-01-4

Basic information

• Product Name: {(R)-1-[(2R,5S)-2-Isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-2-methyl-propyl}-benzene
• Synonyms: {(R)-1-[(2R,5S)-2-Isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-2-methyl-propyl}-benzene
• CAS NO: 222021-01-4
• Molecular Weight: 284.485
• Mol File: 222021-01-4.mol

Chemical Properties

• CAS DataBase Reference: {(R)-1-[(2R,5S)-2-Isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-2-methyl-propyl}-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: {(R)-1-[(2R,5S)-2-Isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-2-methyl-propyl}-benzene(222021-01-4)
• EPA Substance Registry System: {(R)-1-[(2R,5S)-2-Isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-2-methyl-propyl}-benzene(222021-01-4)

Safety Data

• Hazardous Substances Data: 222021-01-4(Hazardous Substances Data)

Upstream product

• 222020-96-4 (1R,2R,5S)-2-i-propyl-5-methyl-1-(3-methyl-1-butyn-1-yl)cyclohexan-1-ol 
• 3391-87-5 l-menthone 
• 598-23-2 3-methyl-but-1-yne 
• 591-51-5 phenyllithium 
• 222020-98-6 Carbonic acid (1S,2R,5S)-2-isopropyl-5-methyl-1-((E)-3-methyl-but-1-enyl)-cyclohexyl ester methyl ester 

Downstream Products

• 19643-71-1 (2S)-3-methyl-2-phenylbutan-1-ol 
• 13490-69-2 (S)-2-phenyl-3-methylbutyric acid 

Relevant articles and documents

Chiral α-substituted carbonyls and alcohols from the S(N)2' displacement of cuprates on chiral carbonates: An alternative to the alkylation of chiral enolates

A highly stereoselective sequence of reactions, based on the anti-selective S(N)2' addition of cuprates to allylic carbonates, transforms alkynes or alkenyl halides into carbonyls having α-chiral centers. The method, which uses menthone as a chiral auxiliary, is a useful alternative to the alkylation of chiral enolates with the added advantage of allowing for the 'alkylation' of sec- and tert-alkyl and aryl groups.

Efficient syntheses of optically active 2-arylalkanoic acids

A highly enantioselective synthesis of 2-axylpropanoic acid was achieved, using a new developed methodology of cuprate addition to chiral carbonates derived from menthone.