222025-84-5

Upstream product

• 79-24-3 Nitroethane 
• 446-52-6 2-Fluorobenzaldehyde 

Downstream Products

• 1494-60-6 2-Nitro-1-<2-fluor-phenyl>-1-<4-fluorphenyl>-propan 
• 222026-91-7 1-benzyl-3-(2-fluoro-phenyl)-4-methyl-1H-pyrrole-2-carboxylic acid tert-butyl ester 
• 222026-81-5 1-allyl-3-(2-fluoro-phenyl)-4-methyl-1H-pyrrole-2-carboxylic acid tert-butyl ester 
• 222026-76-8 3-(2-fluoro-phenyl)-1,4-dimethyl-1H-pyrrole-2-carboxylic acid tert-butyl ester 
• 222026-16-6 3-(2-fluoro-phenyl)-4-methyl-1H-pyrrole-2-carboxylic acid tert-butyl ester 
• 829-40-3 1-fluoro-2-(2-nitroprop-1-en-1-yl)benzene 
• 435326-84-4 5-bromo-2-p-toluenesulfonyl-3-(o-fluorophenyl)-4-methyl-1H-pyrrole 
• 435326-80-0 4-(o-fluorophenyl)-3-methyl-5-p-toluenesulfonylpyrrolin-2-one 
• 435326-82-2 3-(o-fluorophenyl)-4-methyl-2-p-toluenesulfonyl-1H-pyrrole 
• 435326-78-6 4-(o-fluorophenyl)-3-methylpyrrolin-2-one 
• 435326-85-5 1-(o-fluorophenyl)-2-nitro-1-propyl acetate 

Relevant academic research and scientific papers

Fluorophenyl bilirubins: Synthesis and stereochemistry

Analogs of bilirubin with vinyl groups replaced by symmetrically-disposed o-fluorophenyls (1, bis-exo, and 2, bis-endo) were synthesized and characterized spectroscopically. Their 1H NMR spectra and NOE data are consistent with an intramolecularly hydrogen-bonded ridge-tile conformation where each propionic acid group embraces an opposing dipyrrinone. Like bilirubin, 1 and 2 exhibit negative chirality induced circular dichroism (ICD) Cotton effects in chloroform containing quinine. Unlike bilirubin, however, in aqueous buffer containing human serum albumin, 2 exhibits a negative exciton chirality ICD, whereas that of 1 is positive.

Clean five-step synthesis of an array of 1,2,3,4-tetra-substituted pyrroles using polymer-supported reagents

Polymer-supported reagents and other solid sequestering agents may be used to generate an array of 1,2,3,4-tetra-substituted pyrrole derivatives without any chromatographic purification step.