435326-82-2

Upstream product

• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 435326-85-5 1-(o-fluorophenyl)-2-nitro-1-propyl acetate 
• 222025-84-5 1-(o-fluorophenyl)-2-nitro-1-propanol 
• 446-52-6 2-Fluorobenzaldehyde 

Downstream Products

• 435326-83-3 5-bromo-4-(o-fluorophenyl)-3-methyl-2-p-toluenesulfonyl-1H-pyrrole 
• 435326-80-0 4-(o-fluorophenyl)-3-methyl-5-p-toluenesulfonylpyrrolin-2-one 
• 435326-79-7 3-(o-fluorophenyl)-4-methyl-5-p-toluenesulfonylpyrrolin-2-one 
• 435326-78-6 4-(o-fluorophenyl)-3-methylpyrrolin-2-one 
• 435326-84-4 5-bromo-2-p-toluenesulfonyl-3-(o-fluorophenyl)-4-methyl-1H-pyrrole 
• 435326-81-1 4-(o-fluorophenyl)-3-methyl-2-p-toluenesulfonyl-1H-pyrrole 

Relevant academic research and scientific papers

Fluorophenyl bilirubins: Synthesis and stereochemistry

Analogs of bilirubin with vinyl groups replaced by symmetrically-disposed o-fluorophenyls (1, bis-exo, and 2, bis-endo) were synthesized and characterized spectroscopically. Their 1H NMR spectra and NOE data are consistent with an intramolecularly hydrogen-bonded ridge-tile conformation where each propionic acid group embraces an opposing dipyrrinone. Like bilirubin, 1 and 2 exhibit negative chirality induced circular dichroism (ICD) Cotton effects in chloroform containing quinine. Unlike bilirubin, however, in aqueous buffer containing human serum albumin, 2 exhibits a negative exciton chirality ICD, whereas that of 1 is positive.