222036-27-3 Usage
Description
7H-Pyrrolo[2,3-g]benzothiazol-7-one,6,8-dihydro-(9CI) is a chemical compound that serves as an intermediate in the synthesis of Imidazolo-oxindole PKR inhibitor C16 (PKR Inhibitor) (P572500). 7H-Pyrrolo[2,3-g]benzothiazol-7-one,6,8-dihydro-(9CI) plays a crucial role in the development of a drug that acts as a selective inhibitor of the enzyme double-stranded RNA-dependent protein kinase (PKR).
Uses
Used in Pharmaceutical Industry:
7H-Pyrrolo[2,3-g]benzothiazol-7-one,6,8-dihydro-(9CI) is used as an intermediate in the synthesis of PKR Inhibitor for its role in developing a drug that selectively inhibits the enzyme double-stranded RNA-dependent protein kinase (PKR). This inhibition has been shown to effectively suppress PKR function in vivo, leading to neuroprotective and nootropic effects in animal studies.
Used in Neuroprotective Applications:
7H-Pyrrolo[2,3-g]benzothiazol-7-one,6,8-dihydro-(9CI) contributes to the development of a drug with neuroprotective properties, as it is an intermediate in the synthesis of a PKR inhibitor. The inhibition of PKR has been linked to the prevention of neuronal cell death and the promotion of overall brain health.
Used in Nootropic Applications:
7H-Pyrrolo[2,3-g]benzothiazol-7-one,6,8-dihydro-(9CI) is also used in the development of nootropic drugs, which are designed to enhance cognitive function and improve memory. The PKR inhibitor, synthesized using 7H-Pyrrolo[2,3-g]benzothiazol-7-one,6,8-dihydro-(9CI) as an intermediate, has demonstrated nootropic effects in animal studies, suggesting its potential use in improving human cognitive abilities.
Check Digit Verification of cas no
The CAS Registry Mumber 222036-27-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,2,0,3 and 6 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 222036-27:
(8*2)+(7*2)+(6*2)+(5*0)+(4*3)+(3*6)+(2*2)+(1*7)=83
83 % 10 = 3
So 222036-27-3 is a valid CAS Registry Number.
222036-27-3Relevant articles and documents
Substituted oxidole derivatives as protein tyrosine and as protein serine/threonine kinase inhibitors
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, (2008/06/13)
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Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2): Design, synthesis, enzymatic activities, and X-ray crystallographic analysis
Bramson,Holmes,Hunter,Lackey,Lovejoy,Luzzio,Montana,Rocque,Rusnak,Shewchuk,Veal,Corona,Walker,Kuyper,Davis,Dickerson,Edelstein,Frye,Gampe Jr.,Harris,Hassell
, p. 4339 - 4358 (2007/10/03)
Two closely related classes of oxindole-based compounds, 1H-indole-2,3-dione 3-phenylhydrazones and 3-(anilinomethylene)-1,3-dihydro-2H-indol-2-ones, were shown to potently inhibit cyclin-dependent kinase 2 (CDK2). The initial lead compound was prepared as a homologue of the 3-benzylidene-1,3-dihydro-2H-indol-2-one class of kinase inhibitor. Crystallographic analysis of the lead compound bound to CDK2 provided the basis for analogue design. A semiautomated method of ligand docking was used to select compounds for synthesis, and a number of compounds with low nanomolar inhibitory activity versus CDK2 were identified. Enzyme binding determinants for several analogues were evaluated by X-ray crystallography. Compounds in this series inhibited CDK2 with a potency ～10-fold greater than that for CDK1. Members of this class of inhibitor cause an arrest of the cell cycle and have shown potential utility in the prevention of chemotherapy-induced alopecia.
