222036-27-3 Usage
Uses
Used in Pharmaceutical Industry:
7H-Pyrrolo[2,3-g]benzothiazol-7-one,6,8-dihydro-(9CI) is used as an intermediate in the synthesis of PKR Inhibitor for its role in developing a drug that selectively inhibits the enzyme double-stranded RNA-dependent protein kinase (PKR). This inhibition has been shown to effectively suppress PKR function in vivo, leading to neuroprotective and nootropic effects in animal studies.
Used in Neuroprotective Applications:
7H-Pyrrolo[2,3-g]benzothiazol-7-one,6,8-dihydro-(9CI) contributes to the development of a drug with neuroprotective properties, as it is an intermediate in the synthesis of a PKR inhibitor. The inhibition of PKR has been linked to the prevention of neuronal cell death and the promotion of overall brain health.
Used in Nootropic Applications:
7H-Pyrrolo[2,3-g]benzothiazol-7-one,6,8-dihydro-(9CI) is also used in the development of nootropic drugs, which are designed to enhance cognitive function and improve memory. The PKR inhibitor, synthesized using 7H-Pyrrolo[2,3-g]benzothiazol-7-one,6,8-dihydro-(9CI) as an intermediate, has demonstrated nootropic effects in animal studies, suggesting its potential use in improving human cognitive abilities.
Check Digit Verification of cas no
The CAS Registry Mumber 222036-27-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,2,0,3 and 6 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 222036-27:
(8*2)+(7*2)+(6*2)+(5*0)+(4*3)+(3*6)+(2*2)+(1*7)=83
83 % 10 = 3
So 222036-27-3 is a valid CAS Registry Number.
222036-27-3Relevant academic research and scientific papers
3-(anilinomethylene) oxindoles
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Page column 47, (2010/02/04)
The present invention relates generally to novel amine substituted oxindole compounds and compositions. Such compounds and compositions have utility as pharmacological agents in treating diseases or conditions alleviated by the inhibition or antagonism of
Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2): Design, synthesis, enzymatic activities, and X-ray crystallographic analysis
Bramson,Holmes,Hunter,Lackey,Lovejoy,Luzzio,Montana,Rocque,Rusnak,Shewchuk,Veal,Corona,Walker,Kuyper,Davis,Dickerson,Edelstein,Frye,Gampe Jr.,Harris,Hassell
, p. 4339 - 4358 (2007/10/03)
Two closely related classes of oxindole-based compounds, 1H-indole-2,3-dione 3-phenylhydrazones and 3-(anilinomethylene)-1,3-dihydro-2H-indol-2-ones, were shown to potently inhibit cyclin-dependent kinase 2 (CDK2). The initial lead compound was prepared as a homologue of the 3-benzylidene-1,3-dihydro-2H-indol-2-one class of kinase inhibitor. Crystallographic analysis of the lead compound bound to CDK2 provided the basis for analogue design. A semiautomated method of ligand docking was used to select compounds for synthesis, and a number of compounds with low nanomolar inhibitory activity versus CDK2 were identified. Enzyme binding determinants for several analogues were evaluated by X-ray crystallography. Compounds in this series inhibited CDK2 with a potency ～10-fold greater than that for CDK1. Members of this class of inhibitor cause an arrest of the cell cycle and have shown potential utility in the prevention of chemotherapy-induced alopecia.
