222050-34-2Relevant academic research and scientific papers
Enantioselective Lewis acid catalyzed Michael reactions of alkylidene malonates. Catalysis by C2-symmetric bis(oxazoline) copper(II) complexes in the synthesis of chiral, differentiated glutarate esters
Evans, David A.,Rovis, Tomislav,Kozlowski, Marisa C.,Downey, C. Wade,Tedrow, Jason S.
, p. 9134 - 9142 (2000)
C2-symmetric bis(oxazoline)-Cu(II) complexes 1 catalyze the Mukaiyama Michael reaction of alkylidene malonates and enolsilanes. The use of hexafluoro-2-propanol is essential to induce catalyst turnover. High enantioselectivities are exhibited b
Effects of extended aryl-substituted bisoxazoline ligands in asymmetric synthesis - Efficient synthesis and application of 4,4′-bis(1-naphthyl)-, 4,4′-bis(2-naphthyl)- and 4,4′-bis(9-anthryl)-2,2′- isopropylidenebis(1,3-oxazolines)
Van Lingen, Hester L.,Van Delft, Floris L.,Storcken, Roy P. M.,Hekking, Koen F. W.,Klaassen, Anouk,Smits, Jan J. M.,Ruskowska, Patrycja,Frelek, Jadwiga,Rutjes, Floris P. J. T.
, p. 4975 - 4987 (2007/10/03)
The steric influence of extended aryl substituents on 2,2′-bis(1,3- oxazollne) ligands was investigated in a series of asymmetric catalytic reactions such as Mukaiyama aldol and Michael reactions, hetero-Diels-Alder processes, and allylic alkylation react
An efficient synthesis of 1-naphthylbis(oxazoline) and exploration of the scope in asymmetric catalysis
Van Lingen, Hester L.,Van de Mortel, Jeroen K. W.,Hekking, Koen F. W.,Van Delft, Floris L.,Sonke, Theo,Rutjes, Floris P. J. T.
, p. 317 - 324 (2007/10/03)
Both enantiomers of 1-naphthylglycine were obtained in 99% ee by enzymatic resolution of the corresponding racemic amino acid amide, giving access to the novel ligands (R)- and (S)-naphthylbis(oxazoline). Initial studies provided insight into the scope an
Enantioselective conjugate addition of silylketene acetals to β-enamidomalonates. Synthesis of β-amino acid derivatives
Sibi, Mukund P.,Chen, Jianxie
, p. 2933 - 2936 (2007/10/03)
(figure presented) Conjugate addition of silylketene acetals or enolsilanes to enamidomalonates proceeds with excellent chemical efficiency and good selectivity using Cu(OTf)2 and a chiral bisoxazoline. The effect of the Lewis acid, ligand, the
