222050-57-9

Upstream product

• 14371-10-9 (E)-3-phenylpropenal 
• 108-59-8 malonic acid dimethyl ester 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 908303-06-0 (R)-2-(3-oxo-1-phenylpropyl)malonic acid dimethyl ester 
• 104-55-2 3-phenyl-propenal 
• 67-56-1 methanol 
• 104-53-0 3-phenyl-propionaldehyde 
• 104-54-1 3-Phenylpropenol 
• 6626-84-2 dimethyl 2-benzylidenepropanedioate 
• 222050-34-2 (3R)-tert-butyl 4,4-dicarbomethoxy-3-phenylbutanethioate 
• 860772-43-6 (E)-1-(1-methyl-1H-imidazole-2-yl)-3-phenylprop-2-en-1-one 

Relevant academic research and scientific papers

Histidine-containing peptide catalysts developed by a facile library screening method

Although peptide catalysts have a high potential for the use as organocatalysts, the optimization of peptide sequences is laborious and time-consuming. To address this issue, a facile screening method for finding efficient aminocatalysts from a peptide li

Merging organocatalysis with transition metal catalysis and using O 2 as the oxidant for enantioselective C-H functionalization of aldehydes

A new catalytic Saegusa oxidation-Michael addition cascade reaction has been developed for the enantioselective β-functionalization of aldehydes. The feature of this research is the combination of organocatalysis and transition-metal catalysis for the asymmetric C-H functionalization which remains an underdeveloped research topic.

Asymmetric oxidative Lewis base catalysis - Unifying iminium and enamine organocatalysis with oxidations

Enantioselective oxidative domino reactions of allylic alcohols to functionalized aldehydes have been developed. The one pot domino oxidation-iminium activation represents a convenient strategy for the enantioselective addition of malonates to allylic alc

Highly enantioselective and recyclable organocatalytic Michael addition of malonates to α,β-unsaturated aldehydes in aqueous media

A new type of pyrrolidine-based organocatalyst, which was developed earlier in our lab, has been found to be very effective for the Michael addition reaction in aqueous solvents involving a wide range of α,β- unsaturated aldehydes and malonate derivatives

DNA-based catalytic enantioselective Michael reactions in water

High, but not dry: A highly enantioselective Michael reaction in water has been developed by using a simple DNA-based catalyst. Enantioselectivities of up to 99% ee could be obtained by using nitromethane and dimethyl malonate as the nucleophiles and αf,β-unsaturated 2-acylimidazoles as the Michael acceptors. The reactions can be performed on a preparative scale and the catalyst can be recycled. (Chemical Equation Presented).

Organocatalytic conjugate addition of malonates to α,β- unsaturated aldehydes: Asymmetric formal synthesis of (-)-paroxetine, chiral lactams, and lactones

(Chemical Equation Presented) In addition: The scope of the title reaction is demonstrated by the synthesis of chiral lactones and lactams. The latter class of compounds is very important for the preparation of the pharmaceutical compounds such as (-)-par

Enantioselective Lewis acid catalyzed Michael reactions of alkylidene malonates. Catalysis by C2-symmetric bis(oxazoline) copper(II) complexes in the synthesis of chiral, differentiated glutarate esters

C2-symmetric bis(oxazoline)-Cu(II) complexes 1 catalyze the Mukaiyama Michael reaction of alkylidene malonates and enolsilanes. The use of hexafluoro-2-propanol is essential to induce catalyst turnover. High enantioselectivities are exhibited b