2221-08-1

Upstream product

• 103-71-9 phenyl isocyanate 
• 102-09-0 bis(phenyl) carbonate 
• 150-30-1 Phenylalanine 
• 15028-44-1 DL-phenylalanine methyl ester 
• 103-72-0 phenyl isothiocyanate 

Downstream Products

• 33558-02-0 N-phenylcarbamoyl-phenylalanine 
• 150-30-1 Phenylalanine 
• 15719-64-9 methylammonium carbonate 
• 62-53-3 aniline 
• 33557-82-3 2-(1-Nitroso-3-phenylureido)-3-phenylpropionsaeure 
• 33557-81-2 2-(3-Nitroso-3-phenylureido)-3-phenylpropionsaeure 

Relevant academic research and scientific papers

Unprecedented one-pot chemocontrolled entry to thioxoimidazolidinones and aminoimidazolones: Synthesis of kinase inhibitor Leucettamine B

A novel and highly chemoselective protocol for the construction of thioxoimidazolidinone and aminoimidazolone frameworks was explored, and the influence of the reaction conditions on product formation was studied to establish two distinct approaches for their selective formation. In this one-pot reaction, ambient temperature generally resulted in the formation of thioxoimidazolidinones, whereas microwave irradiation provided aminoimidazolones exclusively. An attempt to elucidate the observed chemoselectivity is described, and the products were confirmed by X-ray studies. One-pot synthesis toward Leucettamine B, a marine alkaloid, was achieved on the basis of this protocol.

Microwave-assisted solid-phase synthesis of hydantoin derivatives

A microwave-assisted synthesis of 3,5- and 1,3,5-substituted hydantoins starting from various resins for solid-phase combinatorial chemistry has been developed. The hydantoins were synthesized from pre-loaded resins with amino acids via treatment with isocyanate or phenylisocyanate and subsequent intramolecular cyclization. Both reactions were performed under microwave irradiation. We studied the cyclative cleavage leading to hydantoin compounds dependent on the nature of the amino acid and the nucleofuge properties of the resin.

Treatment of immediate hypersensitivity diseases with aryl hydantoins

Novel hydantoin compounds are described of the formula (I): STR1 wherein Ar is phenyl optionally substituted by up to three radicals selected from the group comprising C1-6 alkoxy, halogen, 1,3-dioxol-2-yl, hydroxy C1-4 alkoxy C

Process for the preparation of hydantoin derivatives

Hydantoin derivatives are produced by reacting 1. a glycine derivative, 2. a primary amine, and 3. a diaryl carbonate Thus, various kinds of hydantoin derivatives can be obtained without using an isocyanate.