2221-10-5

Usage

Uses

Used in Pharmaceutical Industry:
2,4-Imidazolidinedione, 1,5-dimethyl-3-phenylis used as a reagent in organic synthesis for the production of various pharmaceutical compounds, including antiepileptic drugs and antihypertensive medications. Its versatility as a building block allows for the creation of a wide range of therapeutic agents.
Used in Antimicrobial Applications:
2,4-Imidazolidinedione, 1,5-dimethyl-3-phenylis used as an antimicrobial agent due to its antibacterial and antifungal properties. It can be incorporated into formulations for the development of new antimicrobial agents to combat resistant strains of bacteria and fungi.
Used in Agricultural Chemistry:
2,4-Imidazolidinedione, 1,5-dimethyl-3-phenylis used in the development of pesticides, where its antimicrobial properties can be harnessed to protect crops from various pathogens, thereby increasing agricultural productivity and crop yield.
Used in Chemical Industry:
As a white, crystalline powder, 2,4-Imidazolidinedione, 1,5-dimethyl-3-phenyl- is utilized in various chemical processes and reactions, contributing to the synthesis of a range of chemical products and intermediates.

Upstream product

• 2221-13-8 3-phenylimidazolidine-2,4-dione 
• 74-88-4 methyl iodide 
• 60-80-0 antipyrine 
• 83-07-8 4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one 
• 479-92-5 propyphenazone 
• 3615-24-5 ramifenazone 
• 2139-47-1 nifenazone 
• 68-89-3 metamizol 
• 600-21-5 N-methylalanine 
• 103-71-9 phenyl isocyanate 
• 124004-48-4 ethyl 2,3-dimethyl-5-phenylhydantoate 
• 6536-18-1 Morazone 
• 58-15-1 aminopyrine 

Relevant academic research and scientific papers

Changes in the relative contribution of specific and general base catalysis in cationic micelles. The cyclization of substituted ethyl hydantoates

The rate-surfactant profiles for the HO-- and AcO--catalyzed ring closure of two ethyl hydantoates, E2 and E3, to hydantoins with three cetyltrimethylammonium salts (CTAX, X = Br-, Cl-, or AcO-) are m

On the disappearance of the gem-dimethyl effect: The base-catalysed cyclization of ethyl hydantoates

Buffer catalysis and solvent kinetic isotope effects in the cyclization of methyl-substituted ethyl hydantoates with ω-N-methyl (MUE) and ω-N-phenyl groups (PUE) have been studied in an attempt to elucidate the changes in mechanism and eventual reversal o

Change of Rate Determining Step Induced by the gem-Dimethyl Effekt

The base-catalysed cyclisation to the hydantoin of 2,2,3-trimethyl-5-phenylhydantoate (2; R1 = R2 = Me) is slower than that of the 2,3-dimethyl compound, even though the acceleration expected from the gem-dimethyl effect is observed for the acid-catalysed

General Acid-Base Catalysed Cyclisation Reactions of a Strained ω-Phenylhydantoic Acid

In relation to model studies on the carboxylation of biotin, the nucleophilic reactivity of a weakly basic urea towards COOH and COO- was characterised by means of the ring-closure of (3) to (4).Owing to the strain introduced by the two methyl groups the reaction was rapid over the whole pH range, being reversible at pH>9.Three general acid-base-catalysed reactions and one uncatalysed reaction were identified, corresponding to a change of the predominant form of catalysis and/or reactive form of the substrate with changing pH.The additional barrier for anionic nucleophilic attack on COO- versus attack on COOH was estimated as ca. 9 kcal mol-1.A comparison between the reactivity of the phenylureido and methylureido anion towards COO- indicated better nucleophilicity by phenylureido anion, despite its lower basicity.The results obtained with the model compound (3) illustrated the possibility of a change to a different rate-determining step for intramolecular reactions of compounds activated by ground-state strain.

(13)C Nuclear Magnetic Resonance Studies on the Conformation of Substituted Hydantoins

A number of hydantoins were synthesized and their (13)C n.m.r. spectra were studied using special solvents and shift reagents.Some interesting features of their conformation were deduced.In the case of hydantoins derived from phenylalanine evidence was fo