479-92-5

Basic information

• Product Name: Propyphenazone
• Synonyms: 1,2-Dihydro-4-isopropyl-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one;1,2-dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl-3h-pyrazol-3-on;1,2-dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl-3H-Pyrazol-3-one;1,2-dihydro-1,5-dimethyl-4-(isopropyl)-2-phenyl-pyrazol-3-one;1-Phenyl-2,3-dimethyl-4-isopropyl-3-pyrazolin-5-one;1-phenyl-2,3-dimethyl-4-isopropyl-5-Pyrazolone;1-Phenyl-2,3-dimethyl-4-isopropylpyrazol-5-one;2,3-Dimethyl-4-isopropyl-1-phenyl-3H-pyrazolin-5-one
• CAS NO: 479-92-5
• Molecular Formula: C₁₄H₁₈N₂O
• Molecular Weight: 230.31
• EINECS: 207-539-2
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Active Pharmaceutical Ingredients;API's
• Mol File: 479-92-5.mol
• Article Data: 0

Chemical Properties

• Melting Point: 102-105°C
• Boiling Point: 372.3°C (rough estimate)
• Flash Point: 123.8 °C
• Appearance: solid
• Density: 1.0371 (rough estimate)
• Vapor Pressure: 0.000347mmHg at 25°C
• Refractive Index: 1.5500 (estimate)
• Storage Temp.: Refrigerator
• Solubility: Slightly soluble in water, freely soluble in ethanol (96 per cent) and in methylene chloride.
• PKA: 1.46±0.65(Predicted)
• Water Solubility: 743.6g/L(25.35 oC)
• Stability: Stable. Incompatible with strong oxidizing agents.
• Merck: 14,7871
• BRN: 204533
• CAS DataBase Reference: Propyphenazone(CAS DataBase Reference)
• NIST Chemistry Reference: Propyphenazone(479-92-5)
• EPA Substance Registry System: Propyphenazone(479-92-5)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• RTECS: CD2800000
• Hazardous Substances Data: 479-92-5(Hazardous Substances Data)

Usage

Description

This uncharacterized alkaloid has been described by Hartsen as occurring in Iso_x0002_pyrum thalictroides L. No chemical or physical characteristics are known.

Chemical Properties

solid

Definition

ChEBI: A pyrazolone derivative that is antipyrine substituted at C-4 by an isopropyl group.

Brand name

539 grippe-dragees;Amipylo-n;Balpiren;Baukal;Caffalgina;Camoplex;Cantacin;Cerebrol;Daturmed;Degripol;Dentocaps a;Dim-antos;Dolibral;Dolo-mineuron;Dysmalgin;Ejcopyrin;Epizon;Escomen;Estesina;Fd 8;Febral;Finigripp;Grippocaps;Heaven;Infantex;Influvit;Isopronazon;Kavapyret;Kuronde;Lysadestat;Mamaslu;Milneuron;Myo-europan;Neuramin;Neuridal;Neuro-spondryl;Nodiras;Noric;Otobacid;Pfeil;Reomin;Retamex;Rheumanol;Rhinivict;Sanalgin-p;Saridon neu;Saridone;Sedospin;Servalgin;Sonotryl;Spalt;Spongamed;Stona;Synpyrin;Vivcet;Wauco-sin;Wecontrin.

World Health Organization (WHO)

Propyphenazone, a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, was introduced in 1951 for the treatment of rheumatic disorders. As it is structurally related to aminophenazone it has been associated with severe blood dyscrasias. However, it cannot be transformed into potentially carcinogenic nitrosamines and has therefore been widely used as a replacement drug for aminophenazone. In certain countries, products containing propyphenazone have now been restricted in their indications, whereas in others they are still available, sometimes as over-the-counter preparations. See also WHO comment for aminophenazone.

References

Hartsen., J. Chem. Soc., 511 (1873) Mirande., Compt. rend., 168,316 (1919)

InChI:InChI=1/C14H18N2O/c1-10(2)13-11(3)15(4)16(14(13)17)12-8-6-5-7-9-12/h5-10H,1-4H3

Upstream product

• 50993-68-5 4-isopropyl-3-methyl-1-phenylpyrazol-5-one 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 525602-01-1 3-[(hydroxyacetamido)methyl]-4-isopropyl-2-methyl-1-phenyl-3-pyrazolin-5-one 
• 525602-00-0 glycinyl-3-hydroxymethylpropyphenazone 
• 83957-89-5 5-(hydroxymethyl)-4-isopropyl-1-methyl-2-phenyl-1H-pyrazol-3(2H)-one 
• 53616-28-7 5-(bromomethyl)-4-isopropyl-1-methyl-2-phenyl-1H-pyrazol-3(2H)-one 
• 1197040-29-1 phenyl isocyanate 
• 96337-44-9 1-phenyl-2-oxo-3-(1'-methylimino)ethyl-3-isopropyl-aziridine 
• 16939-00-7 1-phenyl-3,4-dimethylimidazol-2(1H)-one 
• 103-70-8 Formanilid