2221-76-3Relevant academic research and scientific papers
Annulation by Sequential Doubla Michael Reaction; Synthesis of Decalones and Its Application to the Syntheses of ε-Cadinene, Khusitone and Khusilal
Hagiwara, Hisahiro,Akama, Tsutomu,Okano, Akihiro,Uda, Hisashi
, p. 2173 - 2184 (2007/10/02)
Reaction of kinetic enolates or the trimethylsilyl enol ethers of 1-acetylcyclohexenes with α,β-unsaturated carbonyl compounds affords 4-substituted 1-decalone derivatives under basic or Lewis acidic conditions.The reaction with acrylates of chiral alcohols has achieved 70percent diastereoselection.Application of these reactions has enabled syntheses of ε-cadinene, khusitone and khusial to be accomplished.
Synthesis of Substituted 2-Decalones from 1-Acetylcyclohexenes and α-Trimethylsilyl α,β-Unsaturated Carbonyl Compounds by Two-Fold Michael Reactions. Synthesis of (+/-)-Khusitone
Hagiwara, Hisahiro,Akama, Tsutomu,Okano, Akihiro,Uda, Hisashi
, p. 1793 - 1796 (2007/10/02)
The kinetic enolates of 1-acetyl cyclohexenes undergo two-fold Michael reaction with α-trimethylsilyl α,β-unsaturated carbonyl compounds to produce 5-substituted 2-decalones.The application of this reaction has enabled a synthesis of (+/-)-khusitone.
Structure and Absolute Configuration of Khusitoneol, a New C14-Ketoalcohol from Vetiver Oil
Kalsi, P. S.,Arora, G. S.,Chhina, Kiranjot
, p. 496 - 498 (2007/10/02)
Vetiver oil has yielded a new antipodal C14-ketoalcohol designated as khusitoneol.It is a C2-hydroxyl derivative of khusitone (II).The absolute configuration of khusitoneol shown in I has been assigned on the basis of spectral data and chemical correlation with II.Unlike the other typical C14-terpenoids occuring in this oil, khusitoneol displays considerable JH activity.
