222171-12-2

Upstream product

• 128143-89-5 4'-Chloro-2,2':6',2''-terpyridine 
• 221537-14-0 2'-methyl-adenosine 
• 2140-79-6 2'-O-methyl adenosine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 222171-09-7 {9-[4-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-methoxy-tetrahydro-furan-2-yl]-9H-purin-6-yl}-[bis-(4-methoxy-phenyl)-phenyl-methyl]-amine 

Downstream Products

• 222171-14-4 N-{9-[4-hydroxy-3-methoxy-5-([2,2';6',2'']terpyridin-4'-yloxymethyl)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide 

Relevant academic research and scientific papers

Efficient site-specific cleavage of RNA using a terpyridine-copper(II) complex joined to a 2'-O-methyloligonucleotide by a non-flexible linker

A terpyridine-Cu(II) complex conjugated to an antisense 2'O-methyloligonucleotide at the 5'-end cleaved RNA predominantly at the site opposite the 5'-end in moderate yield, but the cleavage yield increased by more than two-fold when a 2'-O-methyloligonucl

Site-specific RNA cleavage using terpyridine · Cu(II)-linked 2'-O- methyloligonucleotides

2'-Deoxy- and 2'-O-methyl-5'-O-terpyridyl derivatives of adenosine and cytidine were synthesized and used to construct 5'-end-modified oligonucleotides. These antisense agents complexed with Cu(II) exclusively cleaved a complementary RNA oligomer at the s